Remogliflozin A

• 常用名: Remogliflozin A
• 英文名: Remogliflozin A
• CAS号: 329045-45-6
• 分子量: 450.53
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₄N₂O₇
• 熔点: N/A
• 闪点: N/A

Remogliflozin A用途

Remogliflozin是SGLT2(钠-葡萄糖协同转运蛋白2)的有效和选择性抑制剂,对人和大鼠SGLT2的Kis分别为12.4和26 nM【1】。

Remogliflozin A名称

• 英文名: (2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-[5-methyl-1-propan-2-yl-4-[(4-propan-2-yloxyphenyl)methyl]pyrazol-3-yl]oxyoxane-3,4,5-triol

Remogliflozin A生物活性

• 描述: Remogliflozin是SGLT2(钠-葡萄糖协同转运蛋白2)的有效和选择性抑制剂,对人和大鼠SGLT2的Kis分别为12.4和26 nM【1】。
• 相关类别:
  研究领域 >> 代谢疾病
  信号通路 >> 跨膜转运 >> SGLT
• 参考文献:

  [1]. Fujimori Y, et al. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther. 2008 Oct;327(1):268-76.

Remogliflozin A物理化学性质

• 分子式: C₂₃H₃₄N₂O₇
• 分子量: 450.53
• 精确质量: 450.23700
• PSA: 126.43000
• LogP: 1.32910
• InChIKey: GSINGUMRKGRYJP-VZWAGXQNSA-N
• SMILES: Cc1c(Cc2ccc(OC(C)C)cc2)c(OC2OC(CO)C(O)C(O)C2O)nn1C(C)C

Remogliflozin A靶点实验

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实验名称：Selectivity ratio of IC50 for human SGLT1 expressed in COS-7 cells to IC50 for human ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5129918

实验名称：Selectivity ratio of Ki for human SGLT1 expressed in COS-7 cells to Ki for human SGLT... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5129919

实验名称：Selectivity for human SGLT2 over human SGLT1 来源：ChEMBL 靶标：N/A External Id：CHEMBL961710

实验名称：AUC(0 to t) in remogliflozin etabonate treated rat at 3 mg/kg, po up to 360 mins by L... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725011

实验名称：Apparent permeability in human Caco-2 cells treated with remogliflozin etabonate by L... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725008

实验名称：AUC(0 to t) in rat at 3 mg/kg, po up to 360 mins by LC-MS/MS analysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725009

实验名称：Oral bioavailability in rat assessed as ratio of AUC at 3 mg/kg up to 360 mins by LC-... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725012

实验名称：Inhibition of human SGLT2 expressed in COS7 cells assessed as reduction in [14C]-AMG ... 来源：ChEMBL 靶标：Sodium/glucose cotransporter 2 External Id：CHEMBL4725002

实验名称：Inhibition of human SGLT1 expressed in COS7 cells assessed as reduction in [14C]-AMG ... 来源：ChEMBL 靶标：Sodium/glucose cotransporter 1 External Id：CHEMBL4725003

实验名称：Intrinsic clearance in human liver microsomes at 30 uM up to 60 mins by LC-MS/MS anal... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4725006

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Remogliflozin A英文别名

• Remogliflozin A
• UNII-13ZPK7A4MJ
• [14C]-Remogliflozin