FM19G11

• 常用名: FM19G11
• 英文名: FM19G11
• CAS号: 329932-55-0
• 分子量: 463.39600
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₁₇N₃O₈
• 熔点: N/A
• 闪点: N/A

FM19G11用途

FM19G11 是一种 hypoxia-inducible factor-1-alpha (HIF-1α) 抑制剂,在 HeLa 细胞中抑制缺氧诱导的荧光素酶活性,其 IC50 值为 80 nM。当 HIF-1α 途径在常氧条件下失活时,FM19G11 会调节其他信号途径,包括 mTOR 和 PI3K/Akt/eNOS。

FM19G11名称

• 中文名: 3-[(2,4-二硝基苯甲酰基)氨基]-苯甲酸2-(4-甲基 苯基)-2-氧乙基酯
• 英文名: [2-(4-methylphenyl)-2-oxoethyl] 3-[(2,4-dinitrobenzoyl)amino]benzoate

FM19G11生物活性

• 描述: FM19G11 是一种 hypoxia-inducible factor-1-alpha (HIF-1α) 抑制剂,在 HeLa 细胞中抑制缺氧诱导的荧光素酶活性,其 IC50 值为 80 nM。当 HIF-1α 途径在常氧条件下失活时,FM19G11 会调节其他信号途径,包括 mTOR 和 PI3K/Akt/eNOS。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 代谢酶/蛋白酶 >> HIF/HIF脯氨酰-羟化酶
  研究领域 >> 神经疾病
• 靶点实验:

  HIF-1α[1]

• 体外研究: FM19G11(30-300nm)抑制HeLa细胞系中的HIFα蛋白[1]。FM19G11(500 n m)促进缺氧条件下少突胶质细胞分化[1]。FM19G11(300 nM；3天)显著抑制缺氧GBM-XD、缺氧T98G和常氧T98G细胞中O6-甲基鸟嘌呤DNA甲基转移酶(MGMT)的mRNA水平[2]。M19G11(300 nM；3天)显著增强替莫唑胺(TMZ)的促凋亡作用,尽管FM19G11本身并不诱导凋亡[2]。细胞活力测定[2]细胞系：GBM-XD和T98G细胞浓度：300 nM孵育时间：3天结果：低氧培养中两种细胞株MGMT表达均显著抑制。正常氧培养的98G细胞中MGMT表达下调。细胞活力测定[2]细胞系：GBM-XD和T98G细胞浓度：300nm孵育时间：3天结果：自身无细胞毒性。增强TMZ对缺氧GBM-XD细胞、缺氧T98G细胞和常氧T98G细胞的细胞毒性。
• 体内研究: FM19G11(髓内注射；1-8周)改善严重脊髓损伤(SCI)的运动能力[3]。FM19G11(髓内注射；8周)诱导GAP43(轴突生长标记物)和RIP(损伤处有髓少突胶质细胞标记物)的表达[3]。
• 参考文献:

  [1]. Victoria MM, et, al. FM19G11, a new hypoxia-inducible factor (HIF) modulator, affects stem cell differentiation status. J Biol Chem. 2010 Jan 8; 285(2): 1333-42.

  [2]. You CG, et, al. FM19G11 inhibits O 6 -methylguanine DNA-methyltransferase expression under both hypoxic and normoxic conditions. Cancer Med. 2018 May 15; 7(7): 3292-3300.

  [3]. Ana AA, et, al. FM19G11 and Ependymal Progenitor/Stem Cell Combinatory Treatment Enhances Neuronal Preservation and Oligodendrogenesis after Severe Spinal Cord Injury. Int J Mol Sci. 2018 Jan 9; 19(1): 200.

FM19G11物理化学性质

• 分子式: C₂₃H₁₇N₃O₈
• 分子量: 463.39600
• 精确质量: 463.10200
• PSA: 167.60000
• LogP: 5.53380
• InChIKey: XVUOIWIIQVGWAJ-UHFFFAOYSA-N
• SMILES: Cc1ccc(C(=O)COC(=O)c2cccc(NC(=O)c3ccc([N+](=O)[O-])cc3[N+](=O)[O-])c2)cc1
• 外观性状: powder，off-white to light brown
• 储存条件: 2-8°C

FM19G11MSDS

FM19G11MSDS英文版

FM19G11安全信息

• 危险品运输编码: NONH for all modes of transport

FM19G11靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：Fluorescence polarization-based biochemical high throughput primary assay to identify... 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=Sialate O-acetylesterase; AltName: Full=H-Lse; AltName: Full=Sialic acid-specific 9-O-acetylesterase; Flags: Precursor [Homo sapiens] External Id：SIAE_INH_FP_1536_1X%INH PRUN

实验名称：Absorbance-based primary biochemical high throughput screening assay to identify acti... 来源：The Scripps Research Institute Molecular Screening Center 靶标：caspase-3 preproprotein [Homo sapiens] External Id：PROCASPASE3_ACT_EPIABS_1536_1X%ACT PRUN

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FM19G11英文别名

• fm19g11