HexylHIBO

• 常用名: HexylHIBO
• 英文名: HexylHIBO
• CAS号: 334887-43-3
• 分子量: 256.29800
• 密度: 1.176 g/cm3
• 沸点: N/A
• 分子式: C₁₂H₂₀N₂O₄
• 熔点: N/A
• 闪点: N/A

HexylHIBO用途

己基Hibo是一种有效的I组mGluR拮抗剂,在mGlu1a和mGlu5a受体上的Kbs分别为140和110μM。己基Hibo降低大鼠的sEPSC[1]。

HexylHIBO名称

• 英文名: 2-amino-3-(4-hexyl-3-oxo-1,2-oxazol-5-yl)propanoic acid

HexylHIBO生物活性

• 描述: 己基Hibo是一种有效的I组mGluR拮抗剂,在mGlu1a和mGlu5a受体上的Kbs分别为140和110μM。己基Hibo降低大鼠的sEPSC[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 体外研究: 因此,环境中的谷氨酸水平会激活mGluRs并调节皮层兴奋性[1]。
• 参考文献:

  [1]. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059.

  [2]. Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89(3):1308-1316.

HexylHIBO物理化学性质

• 密度: 1.176 g/cm3
• 分子式: C₁₂H₂₀N₂O₄
• 分子量: 256.29800
• 精确质量: 256.14200
• PSA: 109.32000
• LogP: 1.74540
• InChIKey: OKJBLHIYOWSQDJ-UHFFFAOYSA-N
• SMILES: CCCCCCc1c(CC(N)C(=O)O)o[nH]c1=O

HexylHIBO靶点实验

查看更多实验

实验名称：Antagonist activity against mGlu1-alpha receptor in chinese hamster ovary cells using... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 1 External Id：CHEMBL821488

实验名称：Excitatory activity in the rat cortical slice model. 来源：ChEMBL 靶标：Rattus norvegicus External Id：CHEMBL784060

实验名称：Antagonist activity against mGlu 5a receptor in chinese hamster ovary cells using sec... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL823385

实验名称：Antagonist activity against mGlu 2 receptor in chinese hamster ovary cells using seco... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 2 External Id：CHEMBL821490

实验名称：Displacement of [3H]CPP from NMDA receptor 来源：ChEMBL 靶标：Glutamate receptor ionotropic, NMDA 3A External Id：CHEMBL749322

实验名称：Antagonist activity against mGlu 4a receptor in chinese hamster ovary cells using sec... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 4 External Id：CHEMBL823942

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Binding affinity for AMPA receptor using [3H]AMPA 来源：ChEMBL 靶标：Glutamate receptor 1 External Id：CHEMBL697888

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HexylHIBO英文别名

• hexylhibo