HexylHIBO

Modify Date: 2024-01-08 17:45:20

HexylHIBO Structure
HexylHIBO structure
Common Name HexylHIBO
CAS Number 334887-43-3 Molecular Weight 256.29800
Density 1.176 g/cm3 Boiling Point N/A
Molecular Formula C12H20N2O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HexylHIBO


HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat[1].

 Names

Name 2-amino-3-(4-hexyl-3-oxo-1,2-oxazol-5-yl)propanoic acid
Synonym More Synonyms

 HexylHIBO Biological Activity

Description HexylHIBO is a potent group I mGluR antagonist with Kbs of 140 and 110 μM at mGlu1a and mGlu5a receptors, respectively. HexylHIBO decreased sEPSC in rat[1].
Related Catalog
In Vitro Thus ambient levels of glutamate tonically activate mGluRs and regulate cortical excitability[1].
References

[1]. Madsen U, et al. Synthesis and pharmacology of 3-isoxazolol amino acids as selective antagonists at group I metabotropic glutamic acid receptors. J Med Chem. 2001;44(7):1051-1059.

[2]. Bandrowski AE, et al, Prince DA. Baseline glutamate levels affect group I and II mGluRs in layer V pyramidal neurons of rat sensorimotor cortex. J Neurophysiol. 2003;89(3):1308-1316.

 Chemical & Physical Properties

Density 1.176 g/cm3
Molecular Formula C12H20N2O4
Molecular Weight 256.29800
Exact Mass 256.14200
PSA 109.32000
LogP 1.74540

 Synonyms

hexylhibo
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