3,6-二溴吲哚-alpha-(1-哌嗪甲基)-9H-咔唑-9-乙醇双盐酸盐

• 常用名: 3,6-二溴吲哚-alpha-(1-哌嗪甲基)-9H-咔唑-9-乙醇双盐酸盐
• 英文名: Bax channel blocker
• CAS号: 335165-68-9
• 分子量: 540.11900
• 密度: N/A
• 沸点: 388.1ºC at 760 mmHg
• 分子式: C₁₉H₂₃Br₂Cl₂N₃O
• 熔点: N/A
• 闪点: 188.5ºC

名称

• 中文名: 3,6-二溴吲哚-alpha-(1-哌嗪甲基)-9H-咔唑-9-乙醇双盐酸盐
• 英文名: 1-(3,6-dibromocarbazol-9-yl)-3-piperazin-1-ylpropan-2-ol,dihydrochloride

生物活性

• 相关类别:
  信号通路 >> 细胞凋亡 >> Bcl-2家族
  研究领域 >> 癌症
• 靶点实验:

  BAX[1]

• 参考文献:

  [1]. Garner TP, et al. Small-molecule allosteric inhibitors of BAX. Nat Chem Biol. 2019 Apr;15(4):322-330.

物理化学性质

• 沸点: 388.1ºC at 760 mmHg
• 分子式: C₁₉H₂₃Br₂Cl₂N₃O
• 分子量: 540.11900
• 闪点: 188.5ºC
• 精确质量: 536.95800
• PSA: 40.43000
• LogP: 5.45630
• InChIKey: KUUJEXLRLIPQQJ-UHFFFAOYSA-N
• SMILES: OC(CN1CCNCC1)Cn1c2ccc(Br)cc2c2cc(Br)ccc21
• 储存条件: 2-8℃

安全信息

• 海关编码: 2933990090

海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

靶点实验

查看更多实验

实验名称：Cytotoxicity against african green monkey BSC1 cells up to 200 uM after 20 to 120 hrs... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1024888

实验名称：In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL690114

实验名称：In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL690113

实验名称：Screen for inhibitors of RMI FANCM (MM2) intereaction 来源：11908 靶标：N/A External Id：RMI-FANCM-MM2

实验名称：Antiviral activity against Vaccinia virus WR in BSC1 cells assessed as protection fro... 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL1024887

实验名称：In vitro inhibition of cytochrome C release in isolated mitochondria by the compound ... 来源：ChEMBL 靶标：HeLa External Id：CHEMBL690115

实验名称：Antiviral activity against Vaccinia virus WR in BSC1 cells assessed as reduction in p... 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL1024886

实验名称：Inhibition Assay from US Patent US9211296: "Therapeutic compounds for blocking DNA sy... 来源：BindingDB 靶标：N/A External Id：BindingDB_7456_1

实验名称：Inhibition of Vaccinia virus DNA synthesis in by rapid plate assay 来源：ChEMBL 靶标：Vaccinia virus External Id：CHEMBL1024879

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英文别名

• Bax channel blocker