霍香黃酮醇

• 常用名: 霍香黃酮醇
• 英文名: Pachypodol
• CAS号: 33708-72-4
• 分子量: 344.32
• 密度: 1.5±0.1 g/cm3
• 沸点: 598.8±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₆O₇
• 熔点: N/A
• 闪点: 220.7±23.6 °C

霍香黃酮醇用途

Pachypodol在HepG2细胞中发挥抗氧化和细胞保护作用[1]。Pachypodol在体外抑制CaCo 2结肠癌细胞系的生长(IC50=185.6 mM)[2]。

霍香黃酮醇名称

• 中文名: 霍香酮醇
• 英文名: pachypodol

霍香黃酮醇生物活性

• 描述: Pachypodol在HepG2细胞中发挥抗氧化和细胞保护作用[1]。Pachypodol在体外抑制CaCo 2结肠癌细胞系的生长(IC50=185.6 mM)[2]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Kim EK, et al. Pachypodol, a Methoxyflavonoid Isolated from Pogostemon cablin Bentham Exerts Antioxidant and Cytoprotective Effects in HepG2 Cells: Possible Role of ERK-Dependent Nrf2 Activation. Int J Mol Sci. 2019;20(17):4082. Published 2019 Aug 21.

  [2]. Ali HA,et al. Pachypodol, a flavonol from the leaves of Calycopteris floribunda, inhibits the growth of CaCo 2 colon cancer cell line in vitro. Phytother Res. 2008;22(12):1684-1687.

霍香黃酮醇物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 598.8±50.0 °C at 760 mmHg
• 分子式: C₁₈H₁₆O₇
• 分子量: 344.32
• 闪点: 220.7±23.6 °C
• 精确质量: 344.089600
• PSA: 98.36000
• LogP: 2.56
• InChIKey: KQFUXLQBMQGNRT-UHFFFAOYSA-N
• SMILES: COc1cc(O)c2c(=O)c(OC)c(-c3ccc(O)c(OC)c3)oc2c1
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.654
• 储存条件: 2-8℃，干燥，密闭

霍香黃酮醇安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

霍香黃酮醇海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

霍香黃酮醇靶点实验

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实验名称：Maximal non-toxic dose (MNTD) that shows antiviral activity. 来源：ChEMBL 靶标：Enterovirus C External Id：CHEMBL768389

实验名称：Antimicrobial activity against Bacillus subtilis ATCC 6633 at 100 ug/mL by agar dilut... 来源：ChEMBL 靶标：Bacillus subtilis External Id：CHEMBL968161

实验名称：Antimicrobial activity against Escherichia coli ATCC 25922 at 100 ug/mL by agar dilut... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL968163

实验名称：In vivo antitumor activity against mouse L1210 cells 来源：ChEMBL 靶标：L1210 External Id：CHEMBL999162

实验名称：Antimicrobial activity against Candida albicans ATCC 10231 at 100 ug/mL by agar dilut... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL968162

实验名称：The ratio of the poliovirus viral titer of the virus control (reduction factor) to th... 来源：ChEMBL 靶标：Enterovirus C External Id：CHEMBL766871

实验名称：HIV Enzyme Data 来源：NIAID 靶标：N/A External Id：HIV Enzyme Data

实验名称：Inhibition of ABCG2 expressed in human NCI-H460 cells assessed as inhibition of PhA a... 来源：ChEMBL 靶标：Broad substrate specificity ATP-binding cassette transporter ABCG2 External Id：CHEMBL1694230

实验名称：Minimal dose which produces titer reduction at 10 ug/mL (mD RF10e3) 来源：ChEMBL 靶标：Enterovirus C External Id：CHEMBL766876

实验名称：Antimicrobial activity against Pseudomonas aeruginosa ATCC 15442 at 100 ug/mL by agar... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL968165

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霍香黃酮醇英文别名

• 5-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxy-4H-chromen-4-one
• 5,4'-dihydroxy-3,3',7-trimethoxyflavone
• quercetin 3,3',7-trimethyl ether
• 4',5-Dihydroxy-3,3',7-trimethoxyflavone
• Pachypodol
• 5,4'-dihydroxy-3,7,3'-trimethoxyflavone
• Quercetin 3,7,3'-trimethyl ether
• 5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-3,7-dimethoxychromen-4-one