SU5205

• 常用名: SU5205
• 英文名: SU5205
• CAS号: 3476-86-6
• 分子量: 239.24400
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₀FNO
• 熔点: N/A
• 闪点: N/A

SU5205用途

SU5205 是 VEGFR2 (FLK-1) 的抑制剂,IC50 值为 9.6 μM。

SU5205名称

• 英文名: (E)-3-[(4-fluorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one

SU5205生物活性

• 描述: SU5205 是 VEGFR2 (FLK-1) 的抑制剂,IC50 值为 9.6 μM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> VEGFR
• 靶点实验:

  Flk-1:9.6 μM (IC50)

• 体外研究: SU5205以5.1μM的IC50抑制配体诱导的血管内皮细胞有丝分裂[1]。
• 参考文献:

  [1]. Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.

SU5205物理化学性质

• 分子式: C₁₅H₁₀FNO
• 分子量: 239.24400
• 精确质量: 239.07500
• PSA: 29.10000
• LogP: 3.45640
• InChIKey: QIERHADIMMFZNE-LCYFTJDESA-N
• SMILES: O=C1Nc2ccccc2C1=Cc1ccc(F)cc1
• 外观性状: 黄色固体
• 储存条件: -20℃

SU5205靶点实验

查看更多实验

实验名称：Antidepressant activity in Swiss albino mouse assessed as immobility at 100 mg/kg, po... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3636223

实验名称：Ratio of compound IC50 to SU-5416 IC50 for VEGFR 来源：ChEMBL 靶标：N/A External Id：CHEMBL1068589

实验名称：Antidepressant activity in Swiss albino mouse assessed as decrease in immobility time... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3636221

实验名称：Antidepressant activity in Swiss albino mouse assessed as decrease in immobility time... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3636225

实验名称：Antidepressant activity in Swiss albino mouse assessed as immobility at 100 mg/kg, po... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL3636219

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify activators of... 来源：The Scripps Research Institute Molecular Screening Center 靶标：N/A External Id：FBW7_ACT_ALPHA_1536_1X%ACT PRUN

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

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SU5205英文别名

• 3-[(E)-(4-fluorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one
• (E)-3-(4-fluorobenzylidene)indolin-2-one
• SU 5205