SU5205

Modify Date: 2024-01-11 00:28:12

SU5205 Structure
SU5205 structure
Common Name SU5205
CAS Number 3476-86-6 Molecular Weight 239.24400
Density N/A Boiling Point N/A
Molecular Formula C15H10FNO Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SU5205


SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].

 Names

Name (E)-3-[(4-fluorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one
Synonym More Synonyms

 SU5205 Biological Activity

Description SU5205 is an inhibitor of VEGFR2 (FLK-1), with an IC50 of 9.6 μM[1].
Related Catalog
Target

Flk-1:9.6 μM (IC50)

In Vitro SU5205 inhibits ligand-induced endothelial mitogenesis for VEGF with an IC50 of 5.1 μM[1].
References

[1]. Torsten K, et, al. Synthesis and radiopharmacological investigation of 3-[4'-[(18)F]fluorobenzylidene]indolin-2-one as possible tyrosine kinase inhibitor. Bioorg Med Chem. 2009 Nov 15; 17(22): 7732-42.

 Chemical & Physical Properties

Molecular Formula C15H10FNO
Molecular Weight 239.24400
Exact Mass 239.07500
PSA 29.10000
LogP 3.45640
Storage condition -20℃

 Synonyms

3-[(E)-(4-fluorophenyl)methylidene]-1,3-dihydro-2H-indol-2-one
(E)-3-(4-fluorobenzylidene)indolin-2-one
SU 5205
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