GTP 14564

• 常用名: GTP 14564
• 英文名: GTP 14564
• CAS号: 34823-86-4
• 分子量: 234.25
• 密度: 1.321g/cm3
• 沸点: 459.1ºC at 760mmHg
• 分子式: C₁₅H₁₀N₂O
• 熔点: N/A
• 闪点: 240.7ºC

GTP 14564用途

GTP-14564是一种酪氨酸激酶抑制剂,靶向内部串联重复(ITD)和FLT3。GTP-14564抑制Ba/F3白血病细胞中FLT3配体依赖性生长[1]。

GTP 14564名称

• 英文名: 3-phenyl-1H-[1]benzofuro[3,2-c]pyrazole

GTP 14564生物活性

• 描述: GTP-14564是一种酪氨酸激酶抑制剂,靶向内部串联重复(ITD)和FLT3。GTP-14564抑制Ba/F3白血病细胞中FLT3配体依赖性生长[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> FLT3
• 参考文献:

  [1]. Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8.

GTP 14564物理化学性质

• 密度: 1.321g/cm3
• 沸点: 459.1ºC at 760mmHg
• 分子式: C₁₅H₁₀N₂O
• 分子量: 234.25
• 闪点: 240.7ºC
• 精确质量: 234.07900
• PSA: 41.82000
• LogP: 3.97610
• InChIKey: DZQLVVLATXPWBK-UHFFFAOYSA-N
• SMILES: c1ccc(-c2n[nH]c3c2oc2ccccc23)cc1
• 折射率: 1.738

GTP 14564安全信息

• 海关编码: 2934999090

GTP 14564海关

• 海关编码: 2934999090
• 中文概述: 2934999090. 其他杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途
• Summary: 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

GTP 14564靶点实验

查看更多实验

实验名称：Human KIT proto-oncogene receptor tyrosine kinase (Type III RTKs: PDGFR, CSFR, Kit, F... 来源：IUPHAR-DB 靶标：KIT proto-oncogene receptor tyrosine kinase (Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family) [Homo sapiens] External Id：1805_Human

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Delta TM value showing the stabilisation of CAMK2G produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit gamma External Id：CHEMBL3430795

实验名称：Delta TM value showing the stabilisation of CAMK4 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type IV External Id：CHEMBL3430796

实验名称：Delta TM value showing the stabilisation of CAMK2B produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit beta External Id：CHEMBL3430793

实验名称：Human platelet derived growth factor receptor beta (Type III RTKs: PDGFR, CSFR, Kit, ... 来源：IUPHAR-DB 靶标：platelet derived growth factor receptor beta (Type III RTKs: PDGFR, CSFR, Kit, FLT3 receptor family) [Homo sapiens] External Id：1804_Human

实验名称：Delta TM value showing the stabilisation of CAMK2D produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase type II subunit delta External Id：CHEMBL3430794

实验名称：Delta TM value showing the stabilisation of CDK6 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase 6 External Id：CHEMBL3430799

实验名称：Delta TM value showing the stabilisation of CDKL1 produced by compound binding 来源：ChEMBL 靶标：Cyclin-dependent kinase-like 1 External Id：CHEMBL3430800

实验名称：Delta TM value showing the stabilisation of CAMKK2 produced by compound binding 来源：ChEMBL 靶标：Calcium/calmodulin-dependent protein kinase kinase 2 External Id：CHEMBL3430797

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GTP 14564英文别名

• 3-Phenyl-1H-benzofuro<3,2-c>pyrazol