GTP 14564

Modify Date: 2024-01-06 11:40:02

GTP 14564 Structure
GTP 14564 structure
 Common Name GTP 14564
CAS Number 34823-86-4 Molecular Weight 234.25
Density 1.321g/cm3 Boiling Point 459.1ºC at 760mmHg
Molecular Formula C15H10N2O Melting Point N/A
MSDS N/A Flash Point 240.7ºC

 Use of GTP 14564


GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].

 Names

Name 3-phenyl-1H-[1]benzofuro[3,2-c]pyrazole
Synonym More Synonyms

 GTP 14564 Biological Activity

Description GTP-14564 is a tyrosine kinase inhibitor targeting to internal tandem duplication (ITD) and FLT3. GTP-14564 inhibits FLT3 ligand-dependent growth in Ba/F3 leukemia cells[1].
Related Catalog
References

[1]. Murata K, et al. Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J Biol Chem. 2003 Aug 29;278(35):32892-8.  

 Chemical & Physical Properties

Density 1.321g/cm3
Boiling Point 459.1ºC at 760mmHg
Molecular Formula C15H10N2O
Molecular Weight 234.25
Flash Point 240.7ºC
Exact Mass 234.07900
PSA 41.82000
LogP 3.97610
Index of Refraction 1.738

 Safety Information

HS Code 2934999090

 Synthetic Route

3-chloro-1H-benzofuro[3,2-c]pyrazole structure

3-chloro-1H-ben...

CAS#:1094462-18-6

Phenylboronic acid structure

Phenylboronic acid

CAS#:98-80-6

~86%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Sales, Zachary S.; Mani, Neelakandha S. Journal of Organic Chemistry, 2009 , vol. 74, # 2 p. 891 - 894
3-phenyl-8b-p-toluenesulfonylamido-3a,8b-dihydro-1H-benzofuro(3,2-c)pyrazole structure

3-phenyl-8b-p-t...

CAS#:94511-17-8

~98%

Benzenesulfonamide structure

Benzenesulfonamide

CAS#:98-10-2

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-benzoyl-3-p-toluenesulfonylamidobenzofuran structure

2-benzoyl-3-p-t...

CAS#:94511-13-4

~11%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

N/A structure

N/A

CAS#:19726-12-6

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-benzoylbenzofuran-3-one structure

2-benzoylbenzof...

CAS#:5067-18-5

~92%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Zhou, Zhong-Zhen; Zou, Min; Zhou, Jia; Zhou, Chun-Qiong; Deng, Yan-Hong; Chen, Ming-Hui; Gu, Chun-Ping; Jiang, Zhi-Hong; Chen, Wen-Hua; Liu, Shu-Wen Chemical and Pharmaceutical Bulletin, 2011 , vol. 59, # 8 p. 1057 - 1061
3-BROMO-4-CHLOROTOLUENE structure

3-BROMO-4-CHLOR...

CAS#:49615-93-2

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-benzoyl-3-p-toluenesulfonylamidobenzofuran structure

2-benzoyl-3-p-t...

CAS#:94511-13-4

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
N/A structure

N/A

CAS#:94511-15-6

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943
2-Benzoyl-3(2H)-benzofuranone structure

2-Benzoyl-3(2H)...

CAS#:2030-45-7

~%

GTP 14564 Structure

GTP 14564

CAS#:34823-86-4

Literature: Mosher,W.A. et al. Journal of Organic Chemistry, 1972 , vol. 37, p. 2402 - 2405
2-benzoyl-3-p-toluenesulfonylamidobenzofuran structure

2-benzoyl-3-p-t...

CAS#:94511-13-4

~%

Benzenesulfonamide structure

Benzenesulfonamide

CAS#:98-10-2

3-phenyl-8b-p-toluenesulfonylamido-3a,8b-dihydro-1H-benzofuro(3,2-c)pyrazole structure

3-phenyl-8b-p-t...

CAS#:94511-17-8

N/A structure

N/A

CAS#:94511-15-6

Detail
Literature: Gatta; Settimj Journal of Heterocyclic Chemistry, 1984 , vol. 21, # 4 p. 937 - 943

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

3-Phenyl-1H-benzofuro<3,2-c>pyrazol
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Chemsrc provides GTP 14564(CAS#:34823-86-4) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of GTP 14564 are included as well.>> amp version: GTP 14564

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