Triamcinolone acetonide-d6

• 常用名: Triamcinolone acetonide-d6
• 英文名: Triamcinolone acetonide-d6
• CAS号: 352431-33-5
• 分子量: 440.53
• 密度: 1.3±0.1 g/cm3
• 沸点: 576.9±50.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅D₆FO₆
• 熔点: N/A
• 闪点: 302.7±30.1 °C

Triamcinolone acetonide-d6用途

曲安奈德-d6是氘标记的曲安奈德。

Triamcinolone acetonide-d6名称

• 英文名: (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8,8-bis[(2H3)methyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxol-2-one

Triamcinolone acetonide-d6生物活性

• 描述: 曲安奈德-d6是氘标记的曲安奈德。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 内分泌
  研究领域 >> 炎症/免疫
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 糖皮质激素受体
• 体外研究: 氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
• 参考文献:

  [1]. http://en.wikipedia.org/wiki/Triamcinolone_acetonide

  [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

  [3]. Zhen Xiang, et al. Glucocorticoids improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels. Int J Biol Sci 2020; 16(13):2382-2391.

Triamcinolone acetonide-d6物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 576.9±50.0 °C at 760 mmHg
• 分子式: C₂₄H₂₅D₆FO₆
• 分子量: 440.53
• 闪点: 302.7±30.1 °C
• 精确质量: 440.248138
• LogP: 2.50
• InChIKey: YNDXUCZADRHECN-YOWSACAVSA-N
• SMILES: CC1(C)OC2CC3C4CCC5=CC(=O)C=CC5(C)C4(F)C(O)CC3(C)C2(C(=O)CO)O1
• 蒸汽压: 0.0±3.6 mmHg at 25°C
• 折射率: 1.589

Triamcinolone acetonide-d6靶点实验

查看更多实验

实验名称：uHTS identification of microRNA-mediated mRNA deadenylation inhibitors by fluoresence... 来源：Burnham Center for Chemical Genomics 靶标：polyadenylate-binding protein 1 [Homo sapiens] External Id：SBCCG-A704-MLLE-PAM2-Inh-Primary-Assay

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实验名称：uHTS identification of small molecule inhibitors of Striatal-Enriched Phosphatase via... 来源：Burnham Center for Chemical Genomics 靶标：tyrosine-protein phosphatase non-receptor type 5 isoform a [Homo sapiens] External Id：SBCCG-A754-STEP-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify inh... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor coactivator 3 isoform a [Homo sapiens] External Id：SRC3_INH_LUMI_1536_1X%INH PRUN

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify inh... 来源：The Scripps Research Institute Molecular Screening Center 靶标：nuclear receptor coactivator 1 isoform 1 [Homo sapiens] External Id：SRC1_INH_LUMI_1536_1X%INH PRUN

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

实验名称：Fluorescence-based biochemical high throughput primary assay to identify inhibitors o... 来源：The Scripps Research Institute Molecular Screening Center 靶标：Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] External Id：PLCB3_INH_QFRET_1536_1X%INH PRUN

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Triamcinolone acetonide-d6英文别名

• (4aS,4bR,5S,6aS,6bS,9aR,10aS,10bS)-4b-Fluoro-6b-glycoloyl-5-hydroxy-4a,6a-dimethyl-8,8-bis[(2H3)methyl]-4a,4b,5,6,6a,6b,9a,10,10a,10b,11,12-dodecahydro-2H-naphtho[2',1':4,5]indeno[1,2-d][1,3]dioxo l-2-one