SARS-CoV-2 3CLpro-IN-16

• 常用名: SARS-CoV-2 3CLpro-IN-16
• 英文名: SARS-CoV-2 3CLpro-IN-16
• CAS号: 352659-40-6
• 分子量: 294.37
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₁₄N₂OS
• 熔点: N/A
• 闪点: N/A

SARS-CoV-2 3CLpro-IN-16用途

SARS-CoV-2 3CLpro-IN-16 (Compound 3a) 是一种共价的 SARS-CoV-2 3CLpro 抑制剂(IC50s: 2.124 μM)。SARS-CoV-2 3CLpro-IN-16 与 3CLpro 活性位点结合并与 Cys145 位点形成共价键。

SARS-CoV-2 3CLpro-IN-16名称

• 英文名: SARS-CoV-2 3CLpro-IN-16

SARS-CoV-2 3CLpro-IN-16生物活性

• 描述: SARS-CoV-2 3CLpro-IN-16 (Compound 3a) 是一种共价的 SARS-CoV-2 3CLpro 抑制剂(IC50s: 2.124 μM)。SARS-CoV-2 3CLpro-IN-16 与 3CLpro 活性位点结合并与 Cys145 位点形成共价键。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> SARS冠状病毒
• 靶点实验:

  2.124 μM (SARS-CoV-2 3CLpro)[1]

• 参考文献:

  [1]. Ren P, et al. Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group. J Med Chem. 2023 Aug 18.

SARS-CoV-2 3CLpro-IN-16物理化学性质

• 分子式: C₁₇H₁₄N₂OS
• 分子量: 294.37
• InChIKey: BWJPRMXKIWYPAB-UHFFFAOYSA-N
• SMILES: N#CSCC(=O)N1c2ccccc2CCc2ccccc21

SARS-CoV-2 3CLpro-IN-16靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：A screen for compounds that inhibit the activity of LtaS in Staphylococcus aureus 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School External Id：HMS979

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Inhibition of N-terminal His6-tagged recombinant full length SARS-CoV-2 3CLpro expres... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL5324108

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