11-脱氧前列腺素E2

更新时间：2025-08-25 22:17:44

11-脱氧前列腺素E2结构式	常用名	11-脱氧前列腺素E2	英文名	11-deoxy Prostaglandin E2
	CAS号	35536-53-9	分子量	336.47
	密度	1.1±0.1 g/cm3	沸点	510.3±45.0 °C at 760 mmHg
	分子式	C₂₀H₃₂O₄	熔点	N/A
	MSDS	N/A	闪点	276.5±25.2 °C

11-脱氧前列腺素E2用途

11-Deoxy Prostaglandin E2 是 EP4 选择性激动剂,其 EC50 为0.66 nM。11-Deoxy Prostaglandin E2 是前列腺素 E2 的类似物。11-Deoxy Prostaglandin E2 可用于研究骨愈合、心力衰竭和其他受体相关疾病。

中文名	11-脱氧前列腺素E2
英文名	7-[(1R,2R)-2-[(3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid
英文别名	更多

描述	11-Deoxy Prostaglandin E2 是 EP4 选择性激动剂,其 EC50 为0.66 nM。11-Deoxy Prostaglandin E2 是前列腺素 E2 的类似物。11-Deoxy Prostaglandin E2 可用于研究骨愈合、心力衰竭和其他受体相关疾病。
相关类别	研究领域 >> 癌症信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体
参考文献	[1]. Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37. [2]. Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56.

描述

相关类别

研究领域 >> 癌症

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 前列腺素受体

参考文献

[1]. Holt MC, et al. Improved homology modeling of the human & rat EP4 prostanoid receptors. BMC Mol Cell Biol. 2019 Aug 27;20(1):37.

[2]. Ungrin MD, et al. Key structural features of prostaglandin E(2) and prostanoid analogs involved in binding and activation of the human EP(1) prostanoid receptor. Mol Pharmacol. 2001 Jun;59(6):1446-56.

密度	1.1±0.1 g/cm3
沸点	510.3±45.0 °C at 760 mmHg
分子式	C₂₀H₃₂O₄
分子量	336.47
闪点	276.5±25.2 °C
精确质量	336.230072
PSA	74.60000
LogP	3.41
InChIKey	CTHZICXYLKQMKI-FOSBLDSVSA-N
SMILES	CCCCCC(O)C=CC1CCC(=O)C1CC=CCCCC(=O)O
蒸汽压	0.0±3.0 mmHg at 25°C
折射率	1.543

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：HCMV UL50
External Id：HMS1262

实验名称：Rat EP4 receptor (Prostanoid receptors)
来源：IUPHAR-DB
靶标：EP4 receptor (Prostanoid receptors) [Rattus norvegicus]
External Id：343_Rat

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：N/A
External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151
来源：The Scripps Research Institute Molecular Screening Center
靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL
External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of...
来源：The Scripps Research Institute Molecular Screening Center
External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells
来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School
靶标：Cellular tumor antigen p53
External Id：HMS1485

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11-Deoxy-PGE2

(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,13-dien-1-oic acid