RIPGBM

• 常用名: RIPGBM
• 英文名: RIPGBM
• CAS号: 355406-76-7
• 分子量: 428.45
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₆H₂₁FN₂O₃
• 熔点: N/A
• 闪点: N/A

RIPGBM用途

RIPGBM 是一种选择性的细胞凋亡 (apoptosis) 诱导剂,诱导多形性成胶质细胞瘤 (GBM) 癌症干细胞 (CSCs) 凋亡,EC50≤500 nM。

RIPGBM名称

• 中文名: RIPGBM
• 英文名: RIPGBM

RIPGBM生物活性

• 描述: RIPGBM 是一种选择性的细胞凋亡 (apoptosis) 诱导剂,诱导多形性成胶质细胞瘤 (GBM) 癌症干细胞 (CSCs) 凋亡,EC50≤500 nM。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 靶点实验:

  EC50: ≤500 nM (Apoptosis, in GBM CSCs)[1]

• 体外研究: RIPGBM通过与受体相互作用蛋白激酶2(RIPK2)结合并作为分子开关诱导胱天蛋白酶1依赖性细胞凋亡,这减少了prosurvival RIPK2/TAK1复合物的形成,并增加了促凋亡RIPK2/caspase 1复合物的形成[ 1]。
• 参考文献:

  [1]. Lucki NC, et al. A cell type-selective apoptosis-inducing small molecule for the treatment of brain cancer. Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6435-6440.

RIPGBM物理化学性质

• 分子式: C₂₆H₂₁FN₂O₃
• 分子量: 428.45
• InChIKey: COATXBHZYVUJQP-UHFFFAOYSA-N
• SMILES: CC(=O)N(Cc1ccc(F)cc1)C1=C(NCc2ccccc2)C(=O)c2ccccc2C1=O
• 储存条件: -20°C，干燥，密封

RIPGBM安全信息

• 危害码 (欧洲): Xi

RIPGBM靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1100

实验名称：qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in... 来源：NCGC 靶标：TDP1 protein [Homo sapiens] External Id：TDP1101

实验名称：Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Bas... 来源：Broad Institute 靶标：N/A External Id：2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：High throughput screen for small molecule inhibitors of a hypoxia-regulated fluoresce... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1149-MLP

实验名称：NOVARTIS: Antimalarial liver stage activity measured as a greater than 50% reduction ... 来源：ChEMBL 靶标：Plasmodium yoelii External Id：CHEMBL1789905

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