Α-常春藤素

• 常用名: Α-常春藤素
• 英文名: β-Hederin
• CAS号: 35790-95-5
• 分子量: 734.956
• 密度: 1.3±0.1 g/cm3
• 沸点: 817.8±65.0 °C at 760 mmHg
• 分子式: C₄₁H₆₆O₁₁
• 熔点: 221-223ºC
• 闪点: 240.5±27.8 °C

Α-常春藤素用途

β-Hederin 是一种可从 Hedera helix L.(Araliaceae) 分离得到的皂苷,具有抗利什曼虫活性 (antileishmanial),其在 L. Mexicana promastigotes、L. mexicana amastigotes 和 THP1 细胞中的 IC50 值分别为 1.5 μM、68 nM 和 4.57 μM。

Α-常春藤素名称

• 中文名: beta-常春藤素
• 英文名: (4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
• 中文别名: a－常春藤苷 | Alpha-常春藤皂苷

Α-常春藤素生物活性

• 描述: β-Hederin 是一种可从 Hedera helix L.(Araliaceae) 分离得到的皂苷,具有抗利什曼虫活性 (antileishmanial),其在 L. Mexicana promastigotes、L. mexicana amastigotes 和 THP1 细胞中的 IC50 值分别为 1.5 μM、68 nM 和 4.57 μM。
• 相关类别:
  研究领域 >> 感染
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. F Delmas, et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. Planta Med. 2000 May;66(4):343-7.

  [2]. O Ridoux, et al. In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B. Phytother Res. 2001 Jun;15(4):298-301.

Α-常春藤素物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 817.8±65.0 °C at 760 mmHg
• 熔点: 221-223ºC
• 分子式: C₄₁H₆₆O₁₁
• 分子量: 734.956
• 闪点: 240.5±27.8 °C
• 精确质量: 734.460510
• PSA: 175.37000
• LogP: 9.96
• InChIKey: IBAJNOZMACNWJD-HVUPOBLPSA-N
• SMILES: CC1OC(OC2C(OC3CCC4(C)C(CCC5(C)C4CC=C4C6CC(C)(C)CCC6(C(=O)O)CCC45C)C3(C)C)OCC(O)C2O)C(O)C(O)C1O
• 外观性状: 粉末
• 蒸汽压: 0.0±0.6 mmHg at 25°C
• 折射率: 1.592
• 储存条件: 2-8℃，避光，密封

Α-常春藤素靶点实验

查看更多实验

实验名称：Cell membrane permeabilization in human A549 cells assessed as drug level causing dec... 来源：ChEMBL 靶标：A549 External Id：CHEMBL1031510

实验名称：Cell membrane permeabilization in human DLD1 cells assessed as drug level causing dec... 来源：ChEMBL 靶标：DLD-1 External Id：CHEMBL1031511

实验名称：Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test 来源：ChEMBL 靶标：DLD-1 External Id：CHEMBL1031508

实验名称：Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction test 来源：ChEMBL 靶标：N/A External Id：CHEMBL1031509

实验名称：Toxicity in sheep erythrocytes assessed as induction of hemolysis 来源：ChEMBL 靶标：N/A External Id：CHEMBL1031506

实验名称：Induction of cell cycle arrest in human L02 cells assessed as S phase accumulation at... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4822676

实验名称：Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test 来源：ChEMBL 靶标：A549 External Id：CHEMBL1031507

实验名称：Induction of cell cycle arrest in human L02 cells assessed as G2/M phase accumulation... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4822677

实验名称：Induction of cell cycle arrest in human L02 cells assessed as G0/G1 phase accumulatio... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4822675

实验名称：Induction of apoptosis in human L02 cells assessed as early apoptotic cells at 26 uM ... 来源：ChEMBL 靶标：L02 External Id：CHEMBL4822664

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Α-常春藤素英文别名

• (3β)-3-{[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy}olean-12-en-28-oic acid