β-Hederin

Modify Date: 2024-01-09 11:42:31

β-Hederin structure	Common Name	β-Hederin
	CAS Number	35790-95-5	Molecular Weight	734.956
	Density	1.3±0.1 g/cm3	Boiling Point	817.8±65.0 °C at 760 mmHg
	Molecular Formula	C₄₁H₆₆O₁₁	Melting Point	221-223ºC
	MSDS	N/A	Flash Point	240.5±27.8 °C

Use of β-Hederin

β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively[1][2].

Name	(4aS,6aR,6aS,6bR,8aR,10S,12aR,14bS)-10-[(2S,3R,4S,5S)-4,5-dihydroxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid
Synonym	More Synonyms

Description	β-Hederin, a saponin isolated from Hedera helix L.(Araliaceae), possesses antileishmanial activity. β-Hederin exhibits IC50 values of 1.5 μM, 68 nM and 4.57 μM in L. Mexicana promastigotes, L. mexicana amastigotes and THP1 cells, respectively[1][2].
Related Catalog	Research Areas >> Infection Research Areas >> Inflammation/Immunology
References	[1]. F Delmas, et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. Planta Med. 2000 May;66(4):343-7. [2]. O Ridoux, et al. In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B. Phytother Res. 2001 Jun;15(4):298-301.

Description

Related Catalog

Research Areas >> Infection

Research Areas >> Inflammation/Immunology

References

[1]. F Delmas, et al. Antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A1, as compared to their action on mammalian cells cultured in vitro. Planta Med. 2000 May;66(4):343-7.

[2]. O Ridoux, et al. In vitro antileishmanial activity of three saponins isolated from ivy, alpha-hederin, beta-hederin and hederacolchiside A(1), in association with pentamidine and amphotericin B. Phytother Res. 2001 Jun;15(4):298-301.

Density	1.3±0.1 g/cm3
Boiling Point	817.8±65.0 °C at 760 mmHg
Melting Point	221-223ºC
Molecular Formula	C₄₁H₆₆O₁₁
Molecular Weight	734.956
Flash Point	240.5±27.8 °C
Exact Mass	734.460510
PSA	175.37000
LogP	9.96
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.592