GKK1032B

更新时间：2025-08-25 11:23:58

GKK1032B结构式	常用名	GKK1032B	英文名	GKK1032B
	CAS号	358375-11-8	分子量	501.656
	密度	1.1±0.1 g/cm3	沸点	653.9±55.0 °C at 760 mmHg
	分子式	C₃₂H₃₉NO₄	熔点	N/A
	MSDS	N/A	闪点	349.3±31.5 °C

GKK1032B用途

GKK1032B是一种生物碱化合物,可在内生真菌青霉中发现。GKK1032B可通过激活半胱天冬酶途径诱导人骨肉瘤MG63细胞凋亡[1]。

英文名	GKK1032B
英文别名	更多

描述	GKK1032B是一种生物碱化合物,可在内生真菌青霉中发现。GKK1032B可通过激活半胱天冬酶途径诱导人骨肉瘤MG63细胞凋亡[1]。
相关类别	信号通路 >> 细胞凋亡 >> 细胞凋亡研究领域 >> 癌症
参考文献	[1]. Qi X, et, al. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019 Apr;72(4):237-240. [2]. Liu N, et, al. GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. Chin J Nat Med. 2022 Jan;20(1):67-73.

描述

GKK1032B是一种生物碱化合物,可在内生真菌青霉中发现。GKK1032B可通过激活半胱天冬酶途径诱导人骨肉瘤MG63细胞凋亡[1]。

相关类别

信号通路 >> 细胞凋亡 >> 细胞凋亡

研究领域 >> 癌症

参考文献

[1]. Qi X, et, al. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin-resistant S. aureus. J Antibiot (Tokyo). 2019 Apr;72(4):237-240.

[2]. Liu N, et, al. GKK1032B from endophytic Penicillium citrinum induces the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation. Chin J Nat Med. 2022 Jan;20(1):67-73.

密度	1.1±0.1 g/cm3
沸点	653.9±55.0 °C at 760 mmHg
分子式	C₃₂H₃₉NO₄
分子量	501.656
闪点	349.3±31.5 °C
精确质量	501.287903
LogP	7.78
InChIKey	GAPPHVJLWSRLAC-ZABYPXOYSA-N
SMILES	C=CC1(C)C=C(C)C2C3C(Oc4ccc(cc4)CC4C(=O)NC(=O)C4C(=O)C31)C1C(C)CC(C)CC21C
蒸汽压	0.0±2.0 mmHg at 25°C
折射率	1.560

实验名称：USP8 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin specific peptidase 8
External Id：USP8 FAST DUB HTS Primary

实验名称：USP17 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin specific peptidase 17 like family member 5
External Id：USP17 FAST DUB HTS Primary

实验名称：USP7 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin specific peptidase 7
External Id：USP7 FAST DUB HTS Primary

实验名称：USP28 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin specific peptidase 28
External Id：USP28 FAST DUB HTS Primary

实验名称：USP10 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin specific peptidase 10
External Id：USP10 FAST DUB HTS Primary

实验名称：UCHL1 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin C-terminal hydrolase L1
External Id：UCHL1 FAST DUB HTS Primary

实验名称：OTUD3 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：OTU deubiquitinase 3
External Id：OTUD3 FAST DUB HTS Primary

实验名称：USP30 deubiquitinase inhibition: Primary qHTS
来源：24642
靶标：ubiquitin specific peptidase 30
External Id：USP30 FAST DUB HTS Primary

共8条，当前第1页，共1页

GKK1032B

(3S,4R,5S,7R,9S,10S,13S,14R,16R,20S,27S)-5,7,9,11,13-Pentamethyl-13-vinyl-2-oxa-18-azahexacyclo[20.2.2.13,10.04,9.014,27.016,20]heptacosa-1(24),11,22,25-tetraene-15,17,19-trione