oxyphyllenone a

• 常用名: oxyphyllenone a
• 英文名: oxyphyllenone a
• CAS号: 363610-34-8
• 分子量: 210.27
• 密度: 1.2±0.1 g/cm3
• 沸点: 357.8±42.0 °C at 760 mmHg
• 分子式: C₁₂H₁₈O₃
• 熔点: N/A
• 闪点: 184.4±24.4 °C

oxyphyllenone a用途

Oxyphyllenone A 是 NO Synthase 的抑制剂。Oxyphyllenone A 抑制脂多糖活化的巨噬细胞的 NO 生成,其 IC50 为 28 μM 。

oxyphyllenone a名称

• 英文名: (4aR,7R,8R)-7,8-dihydroxy-4a,8-dimethyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one

oxyphyllenone a生物活性

• 描述: Oxyphyllenone A 是 NO Synthase 的抑制剂。Oxyphyllenone A 抑制脂多糖活化的巨噬细胞的 NO 生成,其 IC50 为 28 μM 。
• 相关类别:
  信号通路 >> 免疫及炎症 >> 一氧化氮合酶
  研究领域 >> 炎症/免疫
• 参考文献:

  [1]. Muraoka O, et al. Absolute stereostructures of novel norcadinane- and trinoreudesmane-type sesquiterpenes with nitric oxide production inhibitory activity from Alpinia oxyphylla. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2217-20.

oxyphyllenone a物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 357.8±42.0 °C at 760 mmHg
• 分子式: C₁₂H₁₈O₃
• 分子量: 210.27
• 闪点: 184.4±24.4 °C
• 精确质量: 210.125595
• PSA: 57.53000
• LogP: 0.51
• InChIKey: ORLGUEREMYIFNG-GLXQMMQGSA-N
• SMILES: CC12CCC(=O)C=C1C(C)(O)C(O)CC2
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.553
• 储存条件: 2-8°C， 密封， 干燥， 避光

oxyphyllenone a靶点实验

查看更多实验

实验名称：Neuroprotective activity in mouse BV2 cells assessed as inhibition of LPS-induced TNF... 来源：ChEMBL 靶标：BV-2 External Id：CHEMBL2399633

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of IFNgamma-... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1953309

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL1953308

实验名称：Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamida... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL940522

实验名称：Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ... 来源：ChEMBL 靶标：Macrophage External Id：CHEMBL942479

实验名称：Inhibition of LPS-induced NO production in ddY mouse macrophages assessed as nitrate ... 来源：ChEMBL 靶标：Macrophage External Id：CHEMBL942478

实验名称：Inhibitory effect on nitric oxide production in lipopolysaccharide activated mouse pe... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL744584

实验名称：Inhibitory effect on nitric oxide production in lipopolysaccharide activated mouse pe... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL744585

实验名称：Inhibitory effect on nitric oxide production in lipopolysaccharide activated mouse pe... 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL743795

实验名称：Inhibition of rat RBL2H3 cell degranulation assessed as inhibition of beta-hexosamida... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL940524

共17条，当前第1页，共2页

1

2

oxyphyllenone a英文别名

• (4aR,7R,8R)-7,8-dihydroxy-4a,8-dimethyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one
• (4aR,7R,8R)-7,8-Dihydroxy-4a,8-dimethyl-4,4a,5,6,7,8-hexahydro-2(3H)-naphthalenone