AGN 195183

• 常用名: AGN 195183
• 英文名: AGN 195183
• CAS号: 367273-07-2
• 分子量: 437.864
• 密度: 1.4±0.1 g/cm3
• 沸点: 500.9±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₂ClF₂NO₄
• 熔点: N/A
• 闪点: 256.7±30.1 °C

AGN 195183用途

AGN 195183是RARα选择性激动剂,Kd为3 nM,相对于AGN 193836有更好的结合选择性,对RARβ/γ无活性。

AGN 195183名称

• 中文名: AGN 195183
• 英文名: AGN 195183

AGN 195183生物活性

• 描述: AGN 195183是RARα选择性激动剂,Kd为3 nM,相对于AGN 193836有更好的结合选择性,对RARβ/γ无活性。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> RAR/RXR
  研究领域 >> 癌症
• 参考文献:

  [1]. Beard RL, et al. Synthesis and biological activity of retinoic acid receptor-alpha specific amides. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3145-8.

AGN 195183物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 500.9±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₂ClF₂NO₄
• 分子量: 437.864
• 闪点: 256.7±30.1 °C
• 精确质量: 437.120544
• LogP: 9.02
• InChIKey: PNAWUIKCVQSLFG-UHFFFAOYSA-N
• SMILES: CC1(C)CCC(C)(C)c2c1cc(C(=O)Nc1cc(F)c(C(=O)O)c(F)c1)c(O)c2Cl
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.596
• 储存条件: 2-8℃

AGN 195183靶点实验

查看更多实验

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Percent inhibition of BrdU incorporation into SK-BR-3 cells 来源：ChEMBL 靶标：SK-BR-3 External Id：CHEMBL804955

实验名称：Percent transcriptional activation of RAR gamma compared to 1 mM ATRA; NA indicates <... 来源：ChEMBL 靶标：Retinoic acid receptor gamma External Id：CHEMBL681084

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Cytotoxicity against African green monkey COS7 cells assessed as cell death after 2 d... 来源：ChEMBL 靶标：COS-7 External Id：CHEMBL4187057

实验名称：Transactivation of mouse Gal4-fused RARalpha-LBD expressed in COS-7 cells after 1 day... 来源：ChEMBL 靶标：Retinoic acid receptor alpha External Id：CHEMBL4187003

实验名称：Transactivation of mouse Gal4-fused RARbeta-LBD expressed in COS-7 cells after 1 day ... 来源：ChEMBL 靶标：Retinoic acid receptor beta External Id：CHEMBL4187005

实验名称：Percent inhibition of BrdU incorporation into T-47D cells 来源：ChEMBL 靶标：T47D External Id：CHEMBL815483

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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AGN 195183英文别名

• 4-{[(4-Chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)carbonyl]amino}-2,6-difluorobenzoic acid
• RC87L028HU
• 4-{[(4-chloro-3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl]amino}-2,6-difluorobenzoic acid
• IRX-5183