TCS-OX2-29

• 常用名: TCS-OX2-29
• 英文名: TCS-OX2-29
• CAS号: 372523-75-6
• 分子量: 397.51
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₃H₃₁N₃O₃
• 熔点: N/A
• 闪点: N/A

TCS-OX2-29用途

TCS-OX2-29是一个强的和选择性的OX2受体拮抗剂，IC50是40 nM。

TCS-OX2-29名称

• 中文名: TCS-OX2-29
• 英文名: TCS OX2 29

TCS-OX2-29生物活性

• 描述: TCS-OX2-29是一个强的和选择性的OX2受体拮抗剂,IC50是40 nM。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 食欲素受体(OX受体)
  研究领域 >> 癌症
• 参考文献:

  [1]. Hirose M et al. N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidicantagonist. Bioorg Med Chem Lett, 2003 Dec 15, 13(24):4497-9.

  [2]. R Mould et al. Binding kinetics differentiates functional antagonism of orexin-2 receptor ligands. Br J Pharmacol. 2014 Jan; 171(2): 351-363.

TCS-OX2-29物理化学性质

• 分子式: C₂₃H₃₁N₃O₃
• 分子量: 397.51
• PSA: 63.69000
• LogP: 4.31880
• InChIKey: COFVZFLCAOUMJT-OAQYLSRUSA-N
• SMILES: COc1cc2c(cc1OC)CN(C(=O)C(NCc1ccncc1)C(C)(C)C)CC2
• 储存条件: 2-8℃

TCS-OX2-29靶点实验

查看更多实验

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (... 来源：NCGC External Id：IP6K1-p1

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu... 来源：NCGC External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu... 来源：NCGC External Id：CYP2C9536

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：NCATS Human Liver Microsomal (HLM) Stability Profiling 来源：NCGC 靶标：N/A External Id：ADME-HLM1

实验名称：Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: lu... 来源：NCGC External Id：CYP3A7681

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Inhibitory concentration against human orexin-2 receptor (hOX2R) 来源：ChEMBL 靶标：Orexin receptor type 2 External Id：CHEMBL757348

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

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TCS-OX2-29英文别名

• 8-Bromo-cGMP,sodium salt
• (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride
• TCS-OX2-29