盐酸吐根酚碱

• 常用名: 盐酸吐根酚碱
• 英文名: Cephaeline dihydrochloride
• CAS号: 3738-70-3
• 分子量: 539.534
• 密度: N/A
• 沸点: N/A
• 分子式: C₂₈H₄₀Cl₂N₂O₄
• 熔点: N/A
• 闪点: N/A

盐酸吐根酚碱用途

盐酸头孢菌素((-)-盐酸头孢菌素)是印度吐根中的一种酚性生物碱。盐酸头孢喹对寨卡病毒(ZIKV)和埃博拉病毒(EBOV)感染均具有有效的抑制作用[1][2]。

盐酸吐根酚碱名称

• 中文名: 盐酸吐根酚碱
• 英文名: cephaeline hydrochloride
• 中文别名: 吐根酚碱盐酸盐(七水)

盐酸吐根酚碱生物活性

• 描述: 盐酸头孢菌素((-)-盐酸头孢菌素)是印度吐根中的一种酚性生物碱。盐酸头孢喹对寨卡病毒(ZIKV)和埃博拉病毒(EBOV)感染均具有有效的抑制作用[1][2]。
• 相关类别:
  信号通路 >> 抗感染 >> 流感病毒
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 丝状病毒
• 参考文献:

  [1]. N.P.Sahu, et al. Determination of emetine and cephaeline in Ipecac roots by high- performance liquid chromatography. Journal of Chromatography A. 1982 Apr; 238( 2):525-529.

  [2]. Yang S, et al. Emetine inhibits Zika and Ebola virus infections through two molecular mechanisms: inhibiting viral replication and decreasing viral entry. Cell Discov. 2018 Jun 5;4:31.

盐酸吐根酚碱物理化学性质

• 分子式: C₂₈H₄₀Cl₂N₂O₄
• 分子量: 539.534
• 精确质量: 538.236511
• PSA: 63.19000
• LogP: 6.51110
• 储存条件: 2-8C

盐酸吐根酚碱靶点实验

查看更多实验

实验名称：Inhibition of HIV1 RT at 200 ug/ml 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL1018095

实验名称：Inhibition of HIV1 RT 来源：ChEMBL 靶标：Reverse transcriptase/RNaseH External Id：CHEMBL1018093

实验名称：Antiviral activity against Ebolavirus infected in african green monkey COS1 cells ass... 来源：ChEMBL 靶标：Ebolavirus External Id：CHEMBL1639010

实验名称：Cytotoxicity against african green monkey COS1 cells assessed as reduction in cell vi... 来源：ChEMBL 靶标：N/A External Id：CHEMBL1639011

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盐酸吐根酚碱英文别名

• 10,11,7'-Trimethoxy-emetan-6'-ol,Hydrochlorid
• AC1NUT82
• CHEBI:2535
• (2R,3R,11bS)-(+)-2-(3,4-dihydro-6-hydroxy-7-methoxy-1-isoquinolyl)methyl-3-ethyl-1,3,4,6,7,11b-hexahydro-8-hydroxy-9,10-dimethoxy-2H-benzo[a]quinolizine (alangicine)
• Alangicine
• 7',10,11-Trimethoxyemetan-6'-ol dihydrochloride
• 2-(6-hydroxy-7-methoxy-3,4-dihydro-isoquinolin-1-ylmethyl)-3-ethyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-8-ol
• Cephaeline dihydrochloride
• 10,11,7'-trimethoxy-emet-1'-ene-9,6'-diol
• Emetan-6'-ol, 7',10,11-trimethoxy-, dihydrochloride (9CI)
• 10,11,7'-trimethoxy-emetan-6'-ol,dihydrochloride
• (2R,3R,11bS)-3-ethyl-2-(6-hydroxy-7-methoxy-3,4-dihydroisoquinolin-1-ylmethyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-8-ol
• 6-Isoquinolinol, 1-[[(2S,3R,11bS)-3-ethyl-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-2H-benzo[a]quinolizin-2-yl]methyl]-1,2,3,4-tetrahydro-7-methoxy-, (1R)-, hydrochloride (1:2)
• 10,11,7'-Trimethoxy-emetan-6'-ol,Dihydrochlorid
• Emetan-6'-ol, 7',10,11-trimethoxy-, dihydrochloride