ALDH3A1-IN-2

• 常用名: ALDH3A1-IN-2
• 英文名: ALDH3A1-IN-2
• CAS号: 374635-48-0
• 分子量: 222.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₁H₁₄N₂O₃
• 熔点: N/A
• 闪点: N/A

ALDH3A1-IN-2用途

ALDH3A1-IN-2(化合物19)是ALDH3A1的有效抑制剂,IC50为1.29μM。醛脱氢酶(ALDHs)在包括前列腺癌在内的各种肿瘤类型中过度表达。ALDH3A1-IN-2具有研究癌症疾病的潜力[1]。

ALDH3A1-IN-2名称

• 英文名: ALDH3A1-IN-2

ALDH3A1-IN-2生物活性

• 描述: ALDH3A1-IN-2(化合物19)是ALDH3A1的有效抑制剂,IC50为1.29μM。醛脱氢酶(ALDHs)在包括前列腺癌在内的各种肿瘤类型中过度表达。ALDH3A1-IN-2具有研究癌症疾病的潜力[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 醛脱氢酶(ALDH)
  研究领域 >> 癌症
• 参考文献:

  [1]. Ibrahim AIM, et al. Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer. J Med Chem. 2022 Mar 10;65(5):3833-3848.

ALDH3A1-IN-2物理化学性质

• 分子式: C₁₁H₁₄N₂O₃
• 分子量: 222.24
• InChIKey: GAIBXTKNUDDQMR-UHFFFAOYSA-N
• SMILES: CCN(CC)c1ccc(C=O)cc1[N+](=O)[O-]

ALDH3A1-IN-2靶点实验

查看更多实验

实验名称：Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as r... 来源：ChEMBL 靶标：DU-145 External Id：CHEMBL5049248

实验名称：Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as r... 来源：ChEMBL 靶标：LNCaP External Id：CHEMBL5049247

实验名称：Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 as... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL5049246

实验名称：Substrate activity at N-terminal-His6 tagged recombinant human ALDH1A1 at 10 uM in pr... 来源：ChEMBL 靶标：Aldehyde dehydrogenase 1A1 External Id：CHEMBL5049237

实验名称：Inhibition of N-terminal-His6 tagged recombinant human ALDH3A1 assessed as reduction ... 来源：ChEMBL 靶标：Aldehyde dehydrogenase, dimeric NADP-preferring External Id：CHEMBL5049236

共5条，当前第1页，共1页

1