Madrasin

• 常用名: Madrasin
• 英文名: Madrasin
• CAS号: 374913-63-0
• 分子量: 311.339
• 密度: 1.4±0.1 g/cm3
• 沸点: 567.2±42.0 °C at 760 mmHg
• 分子式: C₁₆H₁₇N₅O₂
• 熔点: N/A
• 闪点: 296.9±27.9 °C
• 符号: GHS07
• 信号词: Warning

Madrasin用途

Madrasin是一个很强的细胞渗透拼接抑制剂,能够扰乱剪接体组装的前期过程。

Madrasin名称

• 中文名: Madrasin
• 英文名: 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone

Madrasin生物活性

• 描述: Madrasin是一个很强的细胞渗透拼接抑制剂,能够扰乱剪接体组装的前期过程。
• 相关类别:
  信号通路 >> 细胞周期/DNA损伤 >> DNA/RNA合成
  研究领域 >> 癌症
• 参考文献:

  [1]. Andrea Pawellek et al. Identification of Small Molecule Inhibitors of Pre-mRNA Splicing. J Biol Chem, 2014 Dec 12, 289(50): 34683-34698.

Madrasin物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 567.2±42.0 °C at 760 mmHg
• 分子式: C₁₆H₁₇N₅O₂
• 分子量: 311.339
• 闪点: 296.9±27.9 °C
• 精确质量: 311.138214
• LogP: 1.91
• 蒸汽压: 0.0±1.6 mmHg at 25°C
• 折射率: 1.671
• 储存条件: 2-8℃

Madrasin安全信息

• 符号: GHS07
• 信号词: Warning
• 危害声明: H302
• 警示性声明: P301 + P312 + P330
• 危险品运输编码: NONH for all modes of transport

Madrasin靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：CHOP dose-response primary assay 来源：Emory University Molecular Libraries Screening Center 靶标：DNA damage-inducible transcript 3 protein [Mus musculus] External Id：CHOP dose-response primary assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：HTS to identify inhibitors of Caspase inhibitor (zVAD) Induced Cell Death in L929 Cel... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：N/A External Id：HTS to identify inhibitors of Caspase Inhibitor (zVAD) Induced Cell Death in L929 Cells: Confirmation Assays, MH81266

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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Madrasin英文别名

• 2-[(7-methoxy-4-methylquinazolin-2-yl)amino]-5,6-dimethylpyrimidin-4(1H)-one
• 2-[(7-Methoxy-4-methyl-2-quinazolinyl)amino]-5,6-dimethyl-4(1H)-pyrimidinone
• Madrasin