叔辛酚氯

更新时间：2025-08-20 05:27:25

叔辛酚氯结构式	常用名	叔辛酚氯	英文名	Clofoctol
	CAS号	37693-01-9	分子量	365.33700
	密度	1.127 g/cm3	沸点	447.7ºC at 760 mmHg
	分子式	C₂₁H₂₆Cl₂O	熔点	78°
	MSDS	中文版美版	闪点	160.4ºC

叔辛酚氯用途

Clofoctol是一种抗生素, 用于治疗革兰氏阳性菌引起的呼吸道, 耳, 鼻, 咽喉感染。仅对对革兰氏阳性菌起作用, 可渗透入人类肺组织。

中文名	氯福克酚
英文名	2-[(2,4-dichlorophenyl)methyl]-4-(2,4,4-trimethylpentan-2-yl)phenol
中文别名	叔辛酚氯
英文别名	更多

描述	Clofoctol是一种抗生素, 用于治疗革兰氏阳性菌引起的呼吸道, 耳, 鼻, 咽喉感染。仅对对革兰氏阳性菌起作用, 可渗透入人类肺组织。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 感染

密度	1.127 g/cm3
沸点	447.7ºC at 760 mmHg
熔点	78°
分子式	C₂₁H₂₆Cl₂O
分子量	365.33700
闪点	160.4ºC
精确质量	364.13600
PSA	20.23000
LogP	7.00360
InChIKey	HQVZOORKDNCGCK-UHFFFAOYSA-N
SMILES	CC(C)(C)CC(C)(C)c1ccc(O)c(Cc2ccc(Cl)cc2Cl)c1
折射率	1.555
储存条件	2-8°C

叔辛酚氯毒性英文版

危险品运输编码	NONH for all modes of transport
WGK德国	2
RTECS号	SL0533000

Identification of an old antibiotic clofoctol as a novel activator of unfolded protein response pathways and an inhibitor of prostate cancer.

Br. J. Pharmacol. 171(19) , 4478-89, (2014)

Finding new indications for existing drugs, also known as drug repositioning or repurposing, is a powerful approach to accelerate drug discovery and development. The unfolded protein response pathways...

A pharmacokinetic study of clofoctol in human plasma and lung tissue by using a microbiological assay.

Drugs Exp. Clin. Res. 14(1) , 39-43, (1988)

A microbiological assay was undertaken to measure the amounts of clofoctol in human plasma and pulmonary tissue, and to investigate its pharmacokinetics. Clofoctol was extracted from samples using eth...

Alteration of membrane permeability in Bacillus subtilis by clofoctol.

J. Gen. Microbiol. 129(4) , 1089-95, (1983)

When Bacillus subtilis was treated with a bacteriostatic concentration of clofoctol [2-(2,4-dichlorobenzyl)-4-(tetramethyl-1,1,3,3-butyl)phenol], UV-absorbing material was released. Electron micrograp...

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
来源：NCGC
External Id：SNCA-p-activity-luciferase

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来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: lu...
来源：824
External Id：CYP273

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来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

实验名称：qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity
来源：NCGC
External Id：HERG01

实验名称：qHTS for Inhibitors of TGF-b: Cytotox Counterscreen
来源：NCGC
靶标：N/A
External Id：SMAD3201

实验名称：uHTS identification of cystic fibrosis induced NFkb Inhibitors in a fluoresence assay
来源：Burnham Center for Chemical Genomics
靶标：cystic fibrosis transmembrane conductance regulator [Homo sapiens]
External Id：SBCCG-A764-CF-PAF-Primary-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ant...
来源：The Scripps Research Institute Molecular Screening Center
靶标：muscarinic acetylcholine receptor M1 [Homo sapiens]
External Id：CHRM1_ANT_FLUO8_1536_1X%INH PRUN

实验名称：qHTS for Inhibitors of TGF-b
来源：NCGC
靶标：Smad3 [Homo sapiens]
External Id：SMAD3101

实验名称：qHTS Assay for Identifying Compounds that block Entry of Ebola Virus, Screen 2 green ...
来源：NCGC
靶标：N/A
External Id：Ebola screen2_EMI141217_green

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