AK-IN-1

• 常用名: AK-IN-1
• 英文名: AK-IN-1
• CAS号: 378775-98-5
• 分子量: 391.42
• 密度: 1.3±0.1 g/cm3
• 沸点: 593.0±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁N₃O₄
• 熔点: N/A
• 闪点: 312.4±30.1 °C

AK-IN-1用途

AK-IN-1(化合物4072-2732)是一种腺苷激酶(AK)抑制剂,对腺苷(Ado)有竞争性,但对ATP无竞争性。AK-IN-1在浓度为2、4和10µM时分别抑制86%、87%和89%的AK活性。AK-IN-1在许多疾病领域具有良好的研究潜力,包括缺血、炎症和癫痫[1]。

AK-IN-1名称

• 英文名: WAY-239320

AK-IN-1生物活性

• 描述: AK-IN-1(化合物4072-2732)是一种腺苷激酶(AK)抑制剂,对腺苷(Ado)有竞争性,但对ATP无竞争性。AK-IN-1在浓度为2、4和10µM时分别抑制86%、87%和89%的AK活性。AK-IN-1在许多疾病领域具有良好的研究潜力,包括缺血、炎症和癫痫[1]。
• 相关类别:
  信号通路 >> 神经信号通路 >> 腺苷激酶
  研究领域 >> 心血管疾病
  研究领域 >> 炎症/免疫
  研究领域 >> 神经疾病
  信号通路 >> 代谢酶/蛋白酶 >> 腺苷激酶

AK-IN-1物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 593.0±50.0 °C at 760 mmHg
• 分子式: C₂₂H₂₁N₃O₄
• 分子量: 391.42
• 闪点: 312.4±30.1 °C
• 精确质量: 391.153198
• LogP: 3.05
• InChIKey: ARBUGBBNEFAECO-UHFFFAOYSA-N
• SMILES: COc1ccc(-c2oc3ncnc(NCCO)c3c2-c2ccc(OC)cc2)cc1
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.648
• 储存条件: -80℃储存

AK-IN-1靶点实验

查看更多实验

实验名称：Inhibition of protein kinase A (PKA) 来源：ChEMBL 靶标：cAMP-dependent protein kinase catalytic subunit gamma External Id：CHEMBL827919

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：Experimentally measured binding affinity data (Ki) for protein-ligand complexes deriv... 来源：Shanghai Institute of Organic Chemistry 靶标：N/A External Id：PDBbind-Ki for protein-ligand complexes

实验名称：PKA Enzymatic Assay from Article 10.1021/jm049022c: "Structure-based design of novel ... 来源：BindingDB 靶标：N/A External Id：BindingDB_1889_3

实验名称：CDK1 Enzymatic Assay from Article 10.1021/jm049022c: "Structure-based design of novel... 来源：BindingDB 靶标：N/A External Id：BindingDB_1889_2

实验名称：Chk1 Enzymatic Assay from Article 10.1021/jm049022c: "Structure-based design of novel... 来源：BindingDB 靶标：N/A External Id：BindingDB_1889_1

实验名称：Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mit... 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1315

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Inhibition of serine/threonine-protein kinase Chk1 来源：ChEMBL 靶标：Serine/threonine-protein kinase Chk1 External Id：CHEMBL832809

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AK-IN-1英文别名

• 2-{[5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-yl]amino}ethanol
• 2-[5,6-Bis-(4-methoxy-phenyl)-furo[2,3-d]pyrimidin-4-ylamino]-ethanol