他利那新

• 常用名: 他利那新
• 英文名: Tarafenacin
• CAS号: 385367-47-5
• 分子量: 408.389
• 密度: 1.4±0.1 g/cm3
• 沸点: 483.4±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₀F₄N₂O₂
• 熔点: N/A
• 闪点: 246.2±28.7 °C

他利那新用途

Tarafenacin(SVT-40776)是高活性M3毒蕈碱受体选择性拮抗剂，Ki为0.19 nM，比对M2受体的亲和性高200倍。

他利那新名称

• 中文名: 他利那新
• 英文名: [(3R)-1-azabicyclo[2.2.2]octan-3-yl] N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]carbamate

他利那新生物活性

• 描述: Tarafenacin(SVT-40776)是高活性M3毒蕈碱受体选择性拮抗剂,Ki为0.19 nM,比对M2受体的亲和性高200倍。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Salcedo C, et al. In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Br J Pharmacol. 2009 Mar;156(5):807-17.

  [2]. Huang X, et al. Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. J Phys Chem B. 2012 Jan 12;116(1):532-41.

他利那新物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 483.4±45.0 °C at 760 mmHg
• 分子式: C₂₁H₂₀F₄N₂O₂
• 分子量: 408.389
• 闪点: 246.2±28.7 °C
• 精确质量: 408.146088
• PSA: 32.78000
• LogP: 4.59
• InChIKey: UXZDMXYRRQJIBJ-IBGZPJMESA-N
• SMILES: O=C(OC1CN2CCC1CC2)N(Cc1cc(F)c(F)c(F)c1)c1cccc(F)c1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.587
• 储存条件: 2-8℃

他利那新靶点实验

查看更多实验

实验名称：Selectivity ratio of IC50 for human muscarinic M1 receptor to IC50 for human muscarin... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptor M1 and M3 External Id：CHEMBL1781314

实验名称：Selectivity ratio of IC50 for human muscarinic M2 receptor to IC50 for human muscarin... 来源：ChEMBL 靶标：Muscarinic acetylcholine receptors; M2 & M3 External Id：CHEMBL1781313

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

实验名称：Enzymatic assay of human HDAC6 with custom peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808150

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

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他利那新英文别名

• Tarafenacin
• UNII-LDV98UN52Y
• Carbamic acid, N-(3-fluorophenyl)-N-[(3,4,5-trifluorophenyl)methyl]-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
• (3R)-1-Azabicyclo[2.2.2]oct-3-yl (3-fluorophenyl)(3,4,5-trifluorobenzyl)carbamate
• (3R)-1-Az2,4(1Habicyclo(2.2.2)octan-3-yl (3-fluorophenyl)((3,4,5-trifluorophenyl)methyl)carbamate
• Tarafenacin [INN]