EA4

• 常用名: EA4
• 英文名: EA4
• CAS号: 389614-94-2
• 分子量: 340.803
• 密度: 1.3±0.1 g/cm3
• 沸点: 508.3±50.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇ClN₂O₂
• 熔点: N/A
• 闪点: 261.2±30.1 °C

EA4用途

EA4是醌的衍生物,是rPLA和cPLA的抑制剂。EA4可以抑制rPLA2,Ki值为130μ。EA4可用于止血、血栓形成和红细胞生成的研究[1]。

EA4名称

• 英文名: 7-chloro-6-[4-(diethylamino)phenyl]quinoline-5,8-dione

EA4生物活性

• 描述: EA4是醌的衍生物,是rPLA和cPLA的抑制剂。EA4可以抑制rPLA2,Ki值为130μ。EA4可用于止血、血栓形成和红细胞生成的研究[1]。
• 相关类别:
  研究领域 >> 心血管疾病
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
• 靶点实验:

  Ki: 130 μM (rPLA2)[1]

• 体外研究: EA4(9μM,24μM)抑制 rPLA2型和 cPLA2[1]EA4型可抑制 rPLA2,Ki值为 130μM[1]EA4(50μM)以时间依赖性方式显著抑制 23187年诱导的人和牛红细胞释放 AA[1]
• 参考文献:

  [1]. Shin, Hae Sook et al. Purification and characterization of a cytosolic, 42-kDa and Ca2+-dependent phospholipase A2 from bovine red blood cells: its involvement in Ca2+-dependent release of arachidonic acid from mammalian red blood cells. The Journal of biological chemistry vol. 277,23 (2002): 21086-94.

EA4物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 508.3±50.0 °C at 760 mmHg
• 分子式: C₁₉H₁₇ClN₂O₂
• 分子量: 340.803
• 闪点: 261.2±30.1 °C
• 精确质量: 340.097870
• PSA: 50.27000
• LogP: 4.42
• InChIKey: XAZVKSMDPVMMPP-UHFFFAOYSA-N
• SMILES: CCN(CC)c1ccc(C2=C(Cl)C(=O)c3ncccc3C2=O)cc1
• 蒸汽压: 0.0±1.3 mmHg at 25°C
• 折射率: 1.634

EA4靶点实验

查看更多实验

实验名称：Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：HCMV UL50 External Id：HMS1262

实验名称：A screen for small molecules that modulate mitochondrial supercomplex formation 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：N/A External Id：HMS1482

实验名称：Cell-based high throughput primary assay to identify activators of GPR151 来源：The Scripps Research Institute Molecular Screening Center 靶标：RecName: Full=G-protein coupled receptor 151; AltName: Full=G-protein coupled receptor PGR7; AltName: Full=GPCR-2037; AltName: Full=Galanin receptor 4; AltName: Full=Galanin-receptor-like protein; Short=GalRL External Id：GPR151_PHUNTER_AG_LUMI_1536_1X%ACT

实验名称：AlphaScreen-based biochemical high throughput primary assay to identify inhibitors of... 来源：The Scripps Research Institute Molecular Screening Center External Id：MITF_INH_Alpha_1536_1X%INH PRUN

实验名称：Stabilization of p53 in human papillomavirus-positive cells 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Cellular tumor antigen p53 External Id：HMS1485

实验名称：Discovering small molecule activators of G protein-gated inwardly-rectifying potassiu... 来源：15621 靶标：G protein-activated inward rectifier potassium channel 2 External Id：VANDERBILT_HTS_GIRK2_MPD

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EA4英文别名

• 7-Chloro-6-[4-(diethylamino)phenyl]-5,8-quinolinedione
• ea4