特女贞苷

• 常用名: 特女贞苷
• 英文名: Specnuezhenide
• CAS号: 39011-92-2
• 分子量: 686.655
• 密度: 1.5±0.1 g/cm3
• 沸点: 893.8±65.0 °C at 760 mmHg
• 分子式: C₃₁H₄₂O₁₇
• 熔点: N/A
• 闪点: 282.0±27.8 °C

特女贞苷用途

Specnuezhenide ((8E)-Nuezhenide) 是从女贞子的果实中分离出来的。Specnuezhenide ((8E)-Nuezhenide) 可通过抑制 NF-κB 和 wnt/β-catenin 信号传导来抑制 IL-1β 诱导的软骨细胞炎症。Specnuezhenide ((8E)-Nuezhenide) 可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。

特女贞苷名称

• 中文名: 特女贞苷
• 英文名: Nuezhenide

特女贞苷生物活性

• 描述: Specnuezhenide ((8E)-Nuezhenide) 是从女贞子的果实中分离出来的。Specnuezhenide ((8E)-Nuezhenide) 可通过抑制 NF-κB 和 wnt/β-catenin 信号传导来抑制 IL-1β 诱导的软骨细胞炎症。Specnuezhenide ((8E)-Nuezhenide) 可在骨关节炎 (OA) 大鼠模型中发挥抗炎作用。
• 相关类别:
  信号通路 >> 干细胞及 Wnt 通路 >> Wnt信号
  研究领域 >> 炎症/免疫
• 体外研究: Specnuezhenide(0.2-5.0μg/mL)显著降低CoCl2诱导的ARPE-19细胞VEGFA mRNA表达,呈剂量依赖性[2]。
• 参考文献:

  [1]. Ma C, et al. Specnuezhenide Decreases Interleukin-1β-Induced Inflammation in Rat Chondrocytes and Reduces Joint Destruction in Osteoarthritic Rats.Front Pharmacol. 2018 Jun 28;9:700.

  [2]. Wu J, et al. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.Molecules. 2016 Dec 21;21(12). pii: E1756.

特女贞苷物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 893.8±65.0 °C at 760 mmHg
• 分子式: C₃₁H₄₂O₁₇
• 分子量: 686.655
• 闪点: 282.0±27.8 °C
• 精确质量: 686.242188
• PSA: 260.59000
• LogP: -0.31
• InChIKey: STKUCSFEBXPTAY-RDXZJVGFSA-N
• SMILES: CC=C1C(OC2OC(CO)C(O)C(O)C2O)OC=C(C(=O)OC)C1CC(=O)OCC1OC(OCCc2ccc(O)cc2)C(O)C(O)C1O
• 蒸汽压: 0.0±0.3 mmHg at 25°C
• 折射率: 1.636

特女贞苷安全信息

• 安全声明 (欧洲): 24/25
• 海关编码: 29389090

特女贞苷靶点实验

查看更多实验

实验名称：Activation of PPARalpha transfected into HEK cells at 100 uM by luciferase assay 来源：ChEMBL 靶标：Peroxisome proliferator-activated receptor alpha External Id：CHEMBL1103143

实验名称：Inhibition of adipocyte differentiation in mouse 3T3L1 cells assessed as inhibition o... 来源：ChEMBL 靶标：3T3-L1 External Id：CHEMBL1103139

实验名称：Inhibition of adipocyte differentiation in mouse 3T3L1 cells assessed as inhibition o... 来源：ChEMBL 靶标：3T3-L1 External Id：CHEMBL1103138

实验名称：Inhibition of adipocyte differentiation in mouse 3T3L1 cells assessed as inhibition o... 来源：ChEMBL 靶标：3T3-L1 External Id：CHEMBL1102452

实验名称：Inhibition of adipocyte differentiation in mouse 3T3L1 cells assessed as inhibition o... 来源：ChEMBL 靶标：3T3-L1 External Id：CHEMBL1102451

实验名称：Inhibition of GLUT4 来源：ChEMBL 靶标：Solute carrier family 2, facilitated glucose transporter member 4 External Id：CHEMBL1103148

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特女贞苷英文别名

• Specnuezhenide
• 2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside
• β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3E,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate]
• β-D-Glucopyranoside, 2-(4-hydroxyphenyl)ethyl, 6-[2-[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-3,4-dihydro-5-(methoxycarbonyl)-2H-pyran-4-yl]acetate]
• 2-(4-Hydroxyphenyl)ethyl 6-O-{[(2S,3Z,4S)-3-ethylidene-2-(β-D-glucopyranosyloxy)-5-(methoxycarbonyl)-3,4-dihydro-2H-pyran-4-yl]acetyl}-β-D-glucopyranoside
• Specneuzhenide