NSC 185058

• 常用名: NSC 185058
• 英文名: NSC 185058
• CAS号: 39122-38-8
• 分子量: 215.27400
• 密度: 1.323g/cm3
• 沸点: 378.2ºC at 760 mmHg
• 分子式: C₁₁H₉N₃S
• 熔点: N/A
• 闪点: 182.5ºC

NSC 185058用途

NSC 185058 是一种 ATG4B 抑制剂。NSC185058 显著减弱自噬 (autophagic) 活性。

NSC 185058名称

• 中文名: NSC 185058
• 英文名: N-pyridin-2-ylpyridine-2-carbothioamide

NSC 185058生物活性

• 描述: NSC 185058 是一种 ATG4B 抑制剂。NSC185058 显著减弱自噬 (autophagic) 活性。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 自噬 >> 自噬
• 靶点实验:

  Autophagy[1]

• 体外研究: NSC185058是一种ATG4B拮抗剂。 ATG4B通过可逆修饰ATG8促进自噬体形成,从而刺激自噬。包含ATG4B抑制剂NSC185058增强了放射疗法(RT)的抗肿瘤活性。当应用于原位GBM异种移植模型时,NSC185058降低胶质母细胞瘤(GBM)细胞致瘤性,并增强RT的抗肿瘤活性[1]。
• 参考文献:

  [1]. Huang T, et al. MST4 Phosphorylation of ATG4B Regulates Autophagic Activity, Tumorigenicity, and Radioresistance in Glioblastoma. Cancer Cell. 2017 Dec 11;32(6):840-855.e8.

NSC 185058物理化学性质

• 密度: 1.323g/cm3
• 沸点: 378.2ºC at 760 mmHg
• 分子式: C₁₁H₉N₃S
• 分子量: 215.27400
• 闪点: 182.5ºC
• 精确质量: 215.05200
• PSA: 69.90000
• LogP: 2.33720
• InChIKey: UGWOJXZJIZUKDP-UHFFFAOYSA-N
• SMILES: S=C(Nc1ccccn1)c1ccccn1
• 折射率: 1.72
• 储存条件: 2-8℃

NSC 185058靶点实验

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实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Single concentration confirmation of small molecule activators of the apoptotic arm o... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A406-UPR-CHOP-CP-Agonist-Assay

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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NSC 185058英文别名

• 2-Pyridinecarbothioamide,N-2-pyridinyl
• pyridine-2-carbothioic acid pyridin-2-ylamide
• pyridine-2-carbothioic acid-[2]pyridylamide
• Pyridin-2-thiocarbonsaeure-[2]pyridylamid
• N-(2-pyridyl)pyridine-2-thiocarboxamide
• N-2-Pyridylthiopicolinamid
• Thiopicolinsaeureamid-(2-pyridyl)