VU0080241

• 常用名: VU0080241
• 英文名: 1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine
• CAS号: 393845-24-4
• 分子量: 321.419
• 密度: 1.2±0.1 g/cm3
• 沸点: 447.5±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₃N₅
• 熔点: N/A
• 闪点: 224.4±28.7 °C

VU0080241用途

VU0080241是代谢型谷氨酸受体亚型4(mGluR4)的一种正变构调节剂(PAM),EC50为4.6μM[1]。

VU0080241名称

• 英文名: VU0080241

VU0080241生物活性

• 描述: VU0080241是代谢型谷氨酸受体亚型4(mGluR4)的一种正变构调节剂(PAM),EC50为4.6μM[1]。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 谷氨酸受体
  研究领域 >> 神经疾病
• 靶点实验:

  mGlu4:4.6 μM (EC50)

• 参考文献:

  [1]. Colleen M Niswender, et al. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg Med Chem Lett. 2008 Oct 15; 18(20): 5626-5630.

VU0080241物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 447.5±45.0 °C at 760 mmHg
• 分子式: C₁₉H₂₃N₅
• 分子量: 321.419
• 闪点: 224.4±28.7 °C
• 精确质量: 321.195343
• LogP: 4.41
• InChIKey: CLQVVBPDAXJGBV-UHFFFAOYSA-N
• SMILES: Cc1ccc(-n2ncc3c(N4CCCC(C)C4)ncnc32)c(C)c1
• 蒸汽压: 0.0±1.1 mmHg at 25°C
• 折射率: 1.672

VU0080241靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

实验名称：Activity at human mGluR4 expressed in CHO coexpressing Gqi5 assessed as potentiation ... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 4 External Id：CHEMBL995010

实验名称：Activity at rat mGluR5 expressed in HEK cells assessed as fold potentiation of glutam... 来源：ChEMBL 靶标：Metabotropic glutamate receptor 5 External Id：CHEMBL983532

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VU0080241英文别名

• 1-(2,4-Dimethylphenyl)-4-(3-methyl-1-piperidinyl)-1H-pyrazolo[3,4-d]pyrimidine
• VU0080241
• MFCD03474901