4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide

• 常用名: 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide
• 英文名: CMPD-1
• CAS号: 41179-33-3
• 分子量: 349.40
• 密度: 1.229g/cm3
• 沸点: 585ºC at 760 mmHg
• 分子式: C₂₂H₂₀FNO₂
• 熔点: N/A
• 闪点: 307.6ºC

用途

CMPD1 是一种选择性且非 ATP 竞争性的 p38 MAPK 介导的 MK2 磷酸化抑制剂,表观 Ki (Kiapp) 值为 330 nM。

名称

• 中文名: CMPD1
• 英文名: 4-[4-(2-fluorophenyl)phenyl]-N-(4-hydroxyphenyl)butanamide

生物活性

• 描述: CMPD1 是一种选择性且非 ATP 竞争性的 p38 MAPK 介导的 MK2 磷酸化抑制剂,表观 Ki (Kiapp) 值为 330 nM。
• 相关类别:
  信号通路 >> MAPK/ERK信号通路 >> MAPKAPK2(MK2)
  研究领域 >> 癌症
• 靶点实验:

  Kiapp: 330 nM (MK2 phosphorylation)[2]

• 体外研究: CMPD1不抑制p38 MAPK介导的其他两种底物MBP和ATF2的磷酸化[1]。
• 参考文献:

  [1]. Gurgis F, et al. Cytotoxic activity of the MK2 inhibitor CMPD1 in glioblastoma cells is independent of MK2. Cell Death Discov. 2015 Sep 7;1:15028.

  [2]. Davidson W, er al. Discovery and characterization of a substrate selective p38alpha inhibitor. Biochemistry. 2004 Sep 21;43(37):11658-71.

物理化学性质

• 密度: 1.229g/cm3
• 沸点: 585ºC at 760 mmHg
• 分子式: C₂₂H₂₀FNO₂
• 分子量: 349.40
• 闪点: 307.6ºC
• 精确质量: 349.14800
• PSA: 49.33000
• LogP: 5.23270
• InChIKey: ODYAQBDIXCVKAE-UHFFFAOYSA-N
• SMILES: O=C(CCCc1ccc(-c2ccccc2F)cc1)Nc1ccc(O)cc1
• 外观性状: 固体
• 折射率: 1.627
• 储存条件: 2-8°C，密封，干燥

靶点实验

查看更多实验

实验名称：Tocris HTS for Inhibitors of Aerobactin Synthetase lucA 来源：23265 External Id：IucA Pilot Assay Tocris Library

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219380

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 1uM relative to control... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219381

实验名称：Millipore: Percentage of residual kinase activity of PRKAA1 at 10uM relative to contr... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219378

实验名称：Millipore: Percentage of residual kinase activity of PRKAA2 at 1uM relative to contro... 来源：ChEMBL 靶标：5'-AMP-activated protein kinase catalytic subunit alpha-1 External Id：CHEMBL2219379

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 10uM relative to contr... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2218943

实验名称：Millipore: Percentage of residual kinase activity of ABL1 at 1uM relative to control.... 来源：ChEMBL 靶标：Tyrosine-protein kinase ABL1 External Id：CHEMBL2218944

实验名称：Millipore: Percentage of residual kinase activity of NUAK1 at 10uM relative to contro... 来源：ChEMBL 靶标：NUAK family SNF1-like kinase 1 External Id：CHEMBL2219382

实验名称：Millipore: Percentage of residual kinase activity of MAP3K5 at 1uM relative to contro... 来源：ChEMBL 靶标：Mitogen-activated protein kinase kinase kinase 5 External Id：CHEMBL2219383

实验名称：Millipore: Percentage of residual kinase activity of TNK2 at 10uM relative to control... 来源：ChEMBL 靶标：Activated CDC42 kinase 1 External Id：CHEMBL2219372

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英文别名

• CMPD1
• MK2a Inhibitor
• Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor
• MAPKAPK2a Inhibitor