Thiophene-2

更新时间：2026-07-16 19:59:14

Thiophene-2结构式	常用名	Thiophene-2	英文名	TP2
	CAS号	420089-51-6	分子量	419.37
	密度	N/A	沸点	N/A
	分子式	C₁₈H₁₄F₅NO₃S	熔点	N/A
	MSDS	美版	闪点	N/A

Thiophene-2用途

Thiophene-2 (TP2) 是一种特定的 Pks13 抑制剂。Thiophene-2 抑制分枝酸的生物合成,并迅速导致分枝杆菌细胞死亡。Thiophene-2 对结核分枝杆菌具有活性,MIC 值为 1 μM,并具有有效的抗结核活性。

英文名	Thiophene-2
英文别名	更多

描述	Thiophene-2 (TP2) 是一种特定的 Pks13 抑制剂。Thiophene-2 抑制分枝酸的生物合成,并迅速导致分枝杆菌细胞死亡。Thiophene-2 对结核分枝杆菌具有活性,MIC 值为 1 μM,并具有有效的抗结核活性。
相关类别	研究领域 >> 感染信号通路 >> 抗感染 >> 细菌
靶点实验	MIC: 1 μM (Mycobacterium tuberculosis)
体外研究	体外脂肪负荷,抑制脂肪酸激酶3。噻吩-2(TP2；0-125μM)以剂量依赖的方式抑制野生型结核分枝杆菌(Mtb)Pks13(Pks13_-WT)的负载。噻吩-2还抑制棕榈酸(FL C16)负载到抗TP的F79S突变蛋白上[1]。噻吩-2对猴肾Vero细胞和人肝癌HepG2细胞的IC50分别为17.5和7.30μM。当噻吩-2浓度为12.8μM时,在卡介苗感染的J774A.1巨噬细胞内观察到显著的细胞内杀伤活性[1]。
参考文献	[1]. Regina Wilson, et al. Antituberculosis Thiophenes Define a Requirement for Pks13 in Mycolic Acid Biosynthesis. Nat Chem Biol. 2013 Aug;9(8):499-506.

分子式	C₁₈H₁₄F₅NO₃S
分子量	419.37
InChIKey	AVRWEULSKHQETA-UHFFFAOYSA-N
SMILES	COC(=O)c1c(NC(=O)c2c(F)c(F)c(F)c(F)c2F)sc2c1CCCCC2
储存条件	2-8°C，避光，干燥，密封

危害码 (欧洲)	Xi
危险品运输编码	NONH for all modes of transport

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