2-((2,6-二氯苄基)硫基)-5-(吡嗪-2-基)-1,3,4-噻二唑

• 常用名: 2-((2,6-二氯苄基)硫基)-5-(吡嗪-2-基)-1,3,4-噻二唑
• 英文名: Yoda 1
• CAS号: 448947-81-7
• 分子量: 355.265
• 密度: 1.6±0.1 g/cm3
• 沸点: 538.4±60.0 °C at 760 mmHg
• 分子式: C₁₃H₈Cl₂N₄S₂
• 熔点: N/A
• 闪点: 279.4±32.9 °C

用途

GlyT2-IN-1是甘氨酸转运体GLYT2抑制剂, 是一种新型的机械传导通道Piezo1激动剂, 作用于Piezo1-而非载体转染的细胞, 引发Ca2+外流。

名称

• 中文名: GlyT2-IN-1
• 英文名: GlyT2-IN-1

生物活性

• 描述: GlyT2-IN-1是甘氨酸转运体GLYT2抑制剂, 是一种新型的机械传导通道Piezo1激动剂, 作用于Piezo1-而非载体转染的细胞, 引发Ca2+外流。
• 相关类别:
  信号通路 >> 跨膜转运 >> GLYT
  信号通路 >> 神经信号通路 >> GLYT
  研究领域 >> 心血管疾病
• 参考文献:

  [1]. Rousseau F, et al. The glycine transporter GlyT2 controls the dynamics of synaptic vesicle refilling in inhibitory spinal cord neurons. J Neurosci. 2008 Sep 24;28(39):9755-9768.

物理化学性质

• 密度: 1.6±0.1 g/cm3
• 沸点: 538.4±60.0 °C at 760 mmHg
• 分子式: C₁₃H₈Cl₂N₄S₂
• 分子量: 355.265
• 闪点: 279.4±32.9 °C
• 精确质量: 353.956757
• LogP: 4.89
• InChIKey: BQNXBSYSQXSXPT-UHFFFAOYSA-N
• SMILES: Clc1cccc(Cl)c1CSc1nnc(-c2cnccn2)s1
• 蒸汽压: 0.0±1.4 mmHg at 25°C
• 折射率: 1.714
• 储存条件: -20°C，避光干燥

靶点实验

查看更多实验

实验名称：Agonist activity at human PIEZO1 overexpressing HEK293-A cells co-expressing mCherry-... 来源：ChEMBL 靶标：Piezo-type mechanosensitive ion channel component 1 External Id：CHEMBL5510514

实验名称：Agonist activity at human PIEZO1 overexpressing HEK293-A cells co-expressing mCherry-... 来源：ChEMBL 靶标：Piezo-type mechanosensitive ion channel component 1 External Id：CHEMBL5510513

实验名称：Agonist activity at human PIEZO1 overexpressing HEK293-A cells co-expressing mCherry-... 来源：ChEMBL 靶标：Piezo-type mechanosensitive ion channel component 1 External Id：CHEMBL5510512

实验名称：Agonist activity at human PIEZO1 overexpressing HEK293-A cells co-expressing mCherry-... 来源：ChEMBL 靶标：Piezo-type mechanosensitive ion channel component 1 External Id：CHEMBL5510511

实验名称：Agonist activity at human PIEZO1 overexpressing HEK293-A cells co-expressing mCherry-... 来源：ChEMBL 靶标：Piezo-type mechanosensitive ion channel component 1 External Id：CHEMBL5510510

实验名称：Agonist activity at human PIEZO1 overexpressing HEK293-A cells co-expressing mCherry-... 来源：ChEMBL 靶标：Piezo-type mechanosensitive ion channel component 1 External Id：CHEMBL5510509

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VER... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4513082

实验名称：Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Cac... 来源：ChEMBL 靶标：Severe acute respiratory syndrome coronavirus 2 External Id：CHEMBL4303805

实验名称：SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response f... 来源：ChEMBL 靶标：Replicase polyprotein 1ab External Id：CHEMBL4495582

实验名称：Enzymatic assay of human HDAC6 with commercial peptide substrate 来源：ChEMBL 靶标：Histone deacetylase 6 External Id：CHEMBL4808149

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英文别名

• 2-{5-[(2,6-Dichlorobenzyl)sulfanyl]-1,3,4-thiadiazol-2-yl}pyrazine
• 2-[(2,6-dichlorobenzyl)thio]-5-pyrazin-2-yl-1,3,4-thiadiazole
• MFCD00833175