VPC 23019

• 常用名: VPC 23019
• 英文名: VPC 23019
• CAS号: 449173-19-7
• 分子量: 372.39600
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₇H₂₉N₂O₅P
• 熔点: N/A
• 闪点: N/A

VPC 23019用途

VPC23019,一种含芳基酰胺的鞘氨醇 1-磷酸 (S1P) receptor 调节剂,S1P1 和 S1P3 受体的竞争性拮抗剂 (pKis=7.86 和 5.93),S1P4 和 S1P5 的激动剂 (pEC50s=6.58 和 7.07)。

VPC 23019名称

• 中文名: (R)-磷酸单-[2-氨基-2-(3-辛基-苯基氨基甲酰基)-乙基]酯
• 英文名: N-(3-Octylphenyl)-O-phosphono-D-serinamide

VPC 23019生物活性

• 描述: VPC23019,一种含芳基酰胺的鞘氨醇 1-磷酸 (S1P) receptor 调节剂,S1P1 和 S1P3 受体的竞争性拮抗剂 (pKis=7.86 和 5.93),S1P4 和 S1P5 的激动剂 (pEC50s=6.58 和 7.07)。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> LPL受体
  研究领域 >> 炎症/免疫
• 靶点实验:

  pKi: 7.86 (S1P1); 5.93 (S1P3). pEC50: 6.58 (S1P1); 7.07 (S1P3)[1]

• 参考文献:

  [1]. Davis MD, et al. Sphingosine 1-phosphate analogs as receptor antagonists. J Biol Chem. 2005 Mar 18;280(11):9833-41. Epub 2004 Dec 8.

VPC 23019物理化学性质

• 分子式: C₁₇H₂₉N₂O₅P
• 分子量: 372.39600
• 精确质量: 372.18100
• PSA: 135.18000
• LogP: 4.31450
• InChIKey: MRUSUGVVWGNKFE-MRXNPFEDSA-N
• SMILES: CCCCCCCCc1cccc(NC(=O)C(N)COP(=O)(O)O)c1

VPC 23019靶点实验

查看更多实验

实验名称：Efficacy at human S1P3 receptor expressed in HEK293T cells relative to S1P 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 3 External Id：CHEMBL915591

实验名称：Efficacy at human S1P4 receptor expressed in HEK293T cells relative to S1P 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 4 External Id：CHEMBL915592

实验名称：Efficacy at human S1P5 receptor expressed in HEK293T cells relative to S1P 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 5 External Id：CHEMBL915593

实验名称：Activity at human S1P4 receptor expressed in HEK293T cells by [35S]GTP-gamma-S bindin... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 4 External Id：CHEMBL914106

实验名称：Human S1P3 receptor (Lysophospholipid (S1P) receptors) 来源：IUPHAR-DB 靶标：S1P3 receptor (Lysophospholipid (S1P) receptors) [Homo sapiens] External Id：277_Human

实验名称：Activity at human S1P5 receptor expressed in HEK293T cells by [35S]GTP-gamma-S bindin... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 5 External Id：CHEMBL914107

实验名称：Efficacy at human S1P1 receptor expressed in HEK293T cells relative to S1P 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 1 External Id：CHEMBL915589

实验名称：Efficacy at human S1P2 receptor expressed in HEK293T cells relative to S1P 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 2 External Id：CHEMBL915590

实验名称：Activity at human S1P1 receptor expressed in HEK293T cells by [35S]GTP-gamma-S bindin... 来源：ChEMBL 靶标：Sphingosine 1-phosphate receptor 1 External Id：CHEMBL914103

实验名称：Human S1P1 receptor (Lysophospholipid (S1P) receptors) 来源：IUPHAR-DB 靶标：S1P1 receptor (Lysophospholipid (S1P) receptors) [Homo sapiens] External Id：275_Human

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