ML148

• 常用名: ML148
• 英文名: ML148
• CAS号: 451496-96-1
• 分子量: 319.40
• 密度: 1.2±0.1 g/cm3
• 沸点: 543.4±52.0 °C at 760 mmHg
• 分子式: C₂₀H₂₁N₃O
• 熔点: N/A
• 闪点: 282.5±30.7 °C

ML148用途

ML148是一种有效的选择性15-PGDH抑制剂,IC50为56 nM。ML148具有研究前列腺素信号通路的潜力【1】。

ML148名称

• 英文名: [1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone

ML148生物活性

• 描述: ML148是一种有效的选择性15-PGDH抑制剂,IC50为56 nM。ML148具有研究前列腺素信号通路的潜力【1】。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 15-PGDH
  研究领域 >> 炎症/免疫
• 靶点实验:

  IC50: 56 nM (15-PGDH)[1]

• 体外研究: ML148(化合物13)对15-PGDH、ALDH1A1、HADH2、HSD17β4的选择性分别为56、36000、>57500、>57500 nM【1】。当浓度为10 nM时,ML148(10,20 nM)将Vmax降低25%,并将视Km降低一半[1]。
• 参考文献:

  [1]. Niesen FH, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS One. 2010 Nov 2;5(11):e13719.

ML148物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 543.4±52.0 °C at 760 mmHg
• 分子式: C₂₀H₂₁N₃O
• 分子量: 319.40
• 闪点: 282.5±30.7 °C
• 精确质量: 319.168457
• LogP: 3.31
• InChIKey: YQNOQZALLOQMPY-UHFFFAOYSA-N
• SMILES: Cc1cccc(-n2cnc3cc(C(=O)N4CCCCC4)ccc32)c1
• 蒸汽压: 0.0±1.5 mmHg at 25°C
• 折射率: 1.651
• 储存条件: -20°C

ML148靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：NCATS Kinetic Aqueous Solubility Profiling 来源：NCGC 靶标：N/A External Id：ADME-solubility1

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Extended Characterization of HPGD Inhibitors: Activity in Primary Assay (HPGD) 来源：NCGC External Id：hpgd-f4

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Extended Characterization of HPGD Inhibitors: PGE2 Assay in LNCaP Cells 来源：NCGC External Id：hpgd-pge2-LNCaP-f2 (acticity)

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ML148英文别名

• [1-(3-Methylphenyl)-1H-benzimidazol-5-yl](1-piperidinyl)methanone
• [1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone
• 1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-benzimidazole