Topoisomerase II inhibitor 15

• 常用名: Topoisomerase II inhibitor 15
• 英文名: Topoisomerase II inhibitor 15
• CAS号: 451516-79-3
• 分子量: 332.19
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₅H₁₁Cl₂N₅
• 熔点: N/A
• 闪点: N/A

Topoisomerase II inhibitor 15用途

Topoisomerase II inhibitor 15 (compound 2g) 是拓扑异构酶 II (Topoisomerase II) 抑制剂。 Topoisomerase II inhibitor 15 是一种有效的细胞凋亡 (apoptotic) 诱导剂,对头颈部肿瘤具有更高的选择性。

Topoisomerase II inhibitor 15名称

• 英文名: Topoisomerase II inhibitor 15

Topoisomerase II inhibitor 15生物活性

• 描述: Topoisomerase II inhibitor 15 (compound 2g) 是拓扑异构酶 II (Topoisomerase II) 抑制剂。 Topoisomerase II inhibitor 15 是一种有效的细胞凋亡 (apoptotic) 诱导剂,对头颈部肿瘤具有更高的选择性。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
  信号通路 >> 细胞周期/DNA损伤 >> 拓扑异构酶
• 参考文献:

  [1]. Ahmed A Al-Karmalawy, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661.

Topoisomerase II inhibitor 15物理化学性质

• 分子式: C₁₅H₁₁Cl₂N₅
• 分子量: 332.19
• InChIKey: ZDSMMZLZVFAZGS-UHFFFAOYSA-N
• SMILES: NC1=NC(c2ccc(Cl)c(Cl)c2)n2c(nc3ccccc32)N1

Topoisomerase II inhibitor 15靶点实验

查看更多实验

实验名称：Downregulation of IL-6 expression in human HNO 97 cell line assessed as fold change b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5626637

实验名称：Downregulation of BCL2 expression in human HNO 97 cell line assessed as fold change b... 来源：ChEMBL 靶标：N/A External Id：CHEMBL5626638

实验名称：Antioxidant activity against human HNO 97 cell line assessed as increase in GSH level... 来源：ChEMBL 靶标：HNO 97 cell line External Id：CHEMBL5626639

实验名称：Antioxidant activity against human HNO 97 cell line assessed as MDA level measured af... 来源：ChEMBL 靶标：HNO 97 cell line External Id：CHEMBL5626640

实验名称：Antioxidant activity against human HNO 97 cell line assessed as NO level measured aft... 来源：ChEMBL 靶标：HNO 97 cell line External Id：CHEMBL5626641

实验名称：Growth inhibition of human HNO 97 cell line assessed as reduction in cell viability a... 来源：ChEMBL 靶标：HNO 97 cell line External Id：CHEMBL5626613

实验名称：Growth inhibition of human MDA-MB-231 cells assessed as reduction in cell viability a... 来源：ChEMBL 靶标：MDA-MB-231 External Id：CHEMBL5626614

实验名称：Growth inhibition of human HepG2 cells assessed as reduction in cell viability at 100... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL5626615

实验名称：Growth inhibition of human Huh-7 cells assessed as reduction in cell viability at 100... 来源：ChEMBL 靶标：Huh-7 External Id：CHEMBL5626616

实验名称：Growth inhibition of human PC-3 cells assessed as reduction in cell viability at 100 ... 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL5626617

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