Hellebrigenin

• 常用名: Hellebrigenin
• 英文名: Bufotalidin
• CAS号: 465-90-7
• 分子量: 416.50700
• 密度: 1.419g/cm3
• 沸点: 626.3ºC at 760 mmHg
• 分子式: C₂₄H₃₂O₆
• 熔点: 175 °C
• 闪点: 215ºC

Hellebrigenin用途

Hellebrigenin,属于心脏活性类固醇的丁二烯内酯之一,从中药中分离出来。Hellebrigenin 诱导 DNA 损伤和细胞周期 G2/M 阻滞。 Hellebrigenin 触发线粒体介导的细胞凋亡。

Hellebrigenin名称

• 中文名: 蟾蜍它里定
• 英文名: hellebrigenin

Hellebrigenin生物活性

• 描述: Hellebrigenin,属于心脏活性类固醇的丁二烯内酯之一,从中药中分离出来。Hellebrigenin 诱导 DNA 损伤和细胞周期 G2/M 阻滞。 Hellebrigenin 触发线粒体介导的细胞凋亡。
• 相关类别:
  信号通路 >> 细胞凋亡 >> 细胞凋亡
  研究领域 >> 癌症
• 参考文献:

  [1]. Deng LJ, et al. Hellebrigenin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. Chem Biol Interact. 2014 Aug 5;219:184-94.

Hellebrigenin物理化学性质

• 密度: 1.419g/cm3
• 沸点: 626.3ºC at 760 mmHg
• 熔点: 175 °C
• 分子式: C₂₄H₃₂O₆
• 分子量: 416.50700
• 闪点: 215ºC
• 精确质量: 416.22000
• PSA: 107.97000
• LogP: 2.53580
• InChIKey: TVKPTWJPKVSGJB-XHCIOXAKSA-N
• SMILES: CC12CCC3C(CCC4(O)CC(O)CCC34C=O)C1(O)CCC2c1ccc(=O)oc1
• 外观性状: 白色粉末
• 折射率: 1.675
• 储存条件: 2-8°C，密封，干燥

Hellebrigenin毒性和生态

Hellebrigenin靶点实验

查看更多实验

实验名称：Antiangiogenic activity in transgenic Tg(fli1:GFP) zebra fish embryo assessed as redu... 来源：ChEMBL 靶标：Danio rerio External Id：CHEMBL4824091

实验名称：Inhibition of VEGFR2 mediated angiogenesis in transgenic Tg(flk1:GFP) zebra fish embr... 来源：ChEMBL 靶标：Vascular endothelial growth factor receptor 2 External Id：CHEMBL4824092

实验名称：Antiangiogenic activity in transgenic Tg(fli1:GFP) zebra fish embryo assessed as redu... 来源：ChEMBL 靶标：Danio rerio External Id：CHEMBL4824090

实验名称：Inhibitory activity against the primary liver carcinoma (PLC) cell line PLC/PRF/5 来源：ChEMBL 靶标：N/A External Id：CHEMBL763907

实验名称：Toxicity in zebra fish larvae assessed as pericardial edema at 100 uM measured at 48 ... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4824096

实验名称：Inhibitory activity against colchicine resistant parent primary liver carcinoma (PLC)... 来源：ChEMBL 靶标：N/A External Id：CHEMBL763906

实验名称：Induction of apoptosis in human SK-MEL cells assessed as increase in cleaved PARP lev... 来源：ChEMBL 靶标：SK-MEL External Id：CHEMBL4824088

实验名称：Cytotoxicity against human SK-MEL cells assessed as reduction in cell viability measu... 来源：ChEMBL 靶标：SK-MEL External Id：CHEMBL4824085

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Hellebrigenin英文别名

• (3S,5S,8R,9S,10S,13R,14S,17R)-3,5,14-trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-10-carbaldehyde
• EINECS 207-368-3
• Bufotalidin
• Hellebrigenin
• Gellebrigenin