Idalopirdine

更新时间：2025-08-25 19:41:10

Idalopirdine结构式	常用名	Idalopirdine	英文名	Lu AE58054
	CAS号	467459-31-0	分子量	398.370
	密度	1.3±0.1 g/cm3	沸点	500.9±50.0 °C at 760 mmHg
	分子式	C₂₀H₁₉F₅N₂O	熔点	N/A
	MSDS	N/A	闪点	256.7±30.1 °C

Idalopirdine用途

Lu AE58054是5-HT6受体高亲和性拮抗剂，体内外均有较强活性，Ki为0.83 nM。

中文名	Idalopirdine
英文名	2-(6-fluoro-1H-indol-3-yl)-N-[[3-(2,2,3,3-tetrafluoropropoxy)phen yl]methyl]ethanamine
英文别名	更多

描述	Idalopirdine (Lu AE58054) 是有效,选择性的 5-HT6 受体拮抗剂,Ki 为 0.83 nM。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体信号通路 >> 神经信号通路 >> 5-HT受体研究领域 >> 神经疾病
参考文献	[1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33. [2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [?H]Lu AE60157 ([?H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine? (5-HT?) receptors in vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11.

描述

Idalopirdine (Lu AE58054) 是有效,选择性的 5-HT6 受体拮抗剂,Ki 为 0.83 nM。

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 5-HT受体

信号通路 >> 神经信号通路 >> 5-HT受体

研究领域 >> 神经疾病

参考文献

[1]. Arnt J, Bang-Andersen B, Grayson B, Lu AE58054, a 5-HT6 antagonist, reverses cognitive impairment induced by subchronic phencyclidine in a novel object recognition test in rats. Int J Neuropsychopharmacol. 2010 Sep;13(8):1021-33.

[2]. Witten L, Bang-Andersen B, Nielsen SM, Characterization of [?H]Lu AE60157 ([?H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine? (5-HT?) receptors in vivo.Eur J Pharmacol. 2012 Feb 15;676(1-3):6-11.

密度	1.3±0.1 g/cm3
沸点	500.9±50.0 °C at 760 mmHg
分子式	C₂₀H₁₉F₅N₂O
分子量	398.370
闪点	256.7±30.1 °C
精确质量	398.141754
PSA	37.05000
LogP	4.38
InChIKey	YBAWYTYNMZWMMJ-UHFFFAOYSA-N
SMILES	Fc1ccc2c(CCNCc3cccc(OCC(F)(F)C(F)F)c3)c[nH]c2c1
蒸汽压	0.0±1.3 mmHg at 25°C
折射率	1.553
储存条件	2-8℃

实验名称：Primary qHTS assay for small molecule inhibitors of Inositol hexaphosphate kinase 1 (...
来源：NCGC
External Id：IP6K1-p1

实验名称：Human 5-HT6 receptor (5-Hydroxytryptamine receptors)
来源：IUPHAR-DB
靶标：5-HT6 receptor (5-Hydroxytryptamine receptors) [Homo sapiens]
External Id：11_Human

实验名称：Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: lu...
来源：NCGC
External Id：CYP3A4437

实验名称：Cytochrome P450 family 2 subfamily D member 6 (CYP2D6) small molecule antagonists: lu...
来源：NCGC
External Id：CYP2D6395

实验名称：Cytochrome P450 family 2 subfamily C member 9 (CYP2C9) small molecule antagonists: lu...
来源：NCGC
External Id：CYP2C9536

实验名称：Binding affinity to human 5-HT2AR expressed in HEK293 cells by competitive binding as...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 2A
External Id：CHEMBL4316412

实验名称：Displacement of [3H]-LSD from human 5-HT6R expressed in HEK293 cells after 1 hr by mi...
来源：ChEMBL
靶标：5-hydroxytryptamine receptor 6
External Id：CHEMBL4316411

实验名称：Half life in rat liver microsomes up to 60 mins by HPLC-LC/MS analysis
来源：ChEMBL
靶标：N/A
External Id：CHEMBL4316418

实验名称：qHTS assay to identify novel small-molecules to repurpose for Merkel cell carcinoma t...
来源：NCGC
靶标：N/A
External Id：MCC011

实验名称：Primary qHTS for Identification of Calcium Integrin Binding Protein 1 (CIB1) Competit...
来源：NCGC
External Id：CIB1-p1-p2

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