47132-16-1

• 常用中文名：(E)-10-Hydroxynortriptyline
• 常用英文名：(E)-10-Hydroxynortriptyline
• CAS号：47132-16-1
• 分子式：C₁₉H₂₁NO
• 分子量：279.37600
• 相关类别： 研究领域 神经疾病
• 发布时间：2017-03-03 06:25:58
• 更新时间：2026-07-01 09:20:55
• (E)-10-Hydroxynortriptyline (E-10-OH-NT) 是 Nortriptyline (HY-B1417) 的代谢物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。

名称

• 中文名: (E)-5-(3-(甲氨基)丙亚基)-10,11-二氢-5H-二苯并[a,d]轮烯-10-醇
• 英文名: ()-trans-10-hydroxynortriptyline
• 中文别名: 化合物 (E)-10-Hydroxynortriptyline; 氘3-E-10-羟基去甲三环; 盐酸去甲替林杂质13
• 英文别名: E-10-hydroxynortriptyline; (E)-10-Hydroxynortriptyline (raceMic); (E)-10,11-Dihydro-5-(3-(methylamino)propylidene)-5H-dibenzo(A,D)cyclohten-10-ol; trans-10-Hydroxy Nortriptyline Maleate; (E)-5-(3-(methylamino)propylidene)-10,11-dihydro-5H-dibenzo[a,d]annulen-10-ol; TRANS-10-HYDROXYNORTRIPTYLINE; trans-10-hydroxy NortriptylineQ: What is trans-10-hydroxy Nortriptyline Q: What is the CAS Number of trans-10-hydroxy Nortriptyline Q: What is the storage condition of trans-10-hydroxy Nortriptyline; Nortriptyline hydrochloride Impurity 13; 5H-Dibenzo[a,d]cyclohten-10-ol, 10,11-dihydro-5-[3-(methylamino)propylidene]-, (5E); 5H-Dibenzo(A,D)cyclohten-10-ol, 10,11-dihydro-5-(3-(methylamino)propylidene)-, (E); D3-E-10-Hydroxynortriptyline

物化性质

• 密度: 1.164g/cm3
• 沸点: 462.3ºC at 760mmHg
• 分子式: C₁₉H₂₁NO
• 分子量: 279.37600
• 闪点: 142.1ºC
• 精确质量: 279.16200
• PSA: 32.26000
• LogP: 3.70820

生物活性

• 描述: (E)-10-Hydroxynortriptyline (E-10-OH-NT) 是 Nortriptyline (HY-B1417) 的代谢物。Nortriptyline 是三环类抗抑郁药,是 Amitriptyline 的主要活性代谢物,用于缓解抑郁症状。
• 相关类别:
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Shimoda K, et al. The impact of CYP2C19 and CYP2D6 genotypes on metabolism of amitriptyline in Japanese psychiatric patients. J Clin Psychopharmacol. 2002 Aug;22(4):371-8.

  [2]. Shimoda K, et al. Dean L. Amitriptyline Therapy and CYP2D6 and CYP2C19 Genotype. Biotechnology Information (US); 2012-2017 Mar 23.

合成路线

156458-95-6 74-89-5 ~91% 47132-16-1

文献：Jean-Claude; Just Synthetic Communications, 1994 , vol. 24, # 11 p. 1565 - 1573

37439-92-2 ~% 47132-16-1

文献：Jean-Claude; Just Synthetic Communications, 1994 , vol. 24, # 11 p. 1565 - 1573

37508-15-9 ~% 47132-16-1

文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

88086-81-1 ~% 47132-16-1

文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

1562-53-4 ~% 47132-16-1

文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

37439-94-4 ~% 47132-16-1

文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

2099-60-7 ~% 47132-16-1

文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

88086-82-2 ~% 47132-16-1

文献：Lassen; Perregaard 1983 , vol. 37, # 4 B p. 335 - 340

72-69-5 ~% 4444-42-2 47132-19-4 47132-16-1

文献：Masubuchi, Yasuhiro; Iwasa, Takashi; Fujita, Shoichi; Suzuki, Tokuji; Horie, Toshiharu; Narimatsu, Shizuo Journal of Pharmacy and Pharmacology, 1996 , vol. 48, # 9 p. 925 - 929

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