(S)-Bromoenol lactone

• 常用名: (S)-Bromoenol lactone
• 英文名: (S)-Bromoenol lactone
• CAS号: 478288-94-7
• 分子量: 317.177
• 密度: 1.5±0.1 g/cm3
• 沸点: 467.0±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₃BrO₂
• 熔点: N/A
• 闪点: 236.2±28.7 °C

(S)-Bromoenol lactone用途

(S) -溴代醇内酯((S)-BEL)是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶A2β(iPLA2β)抑制剂,可抑制血管加压素诱导的大鼠主动脉平滑肌(A10)细胞释放花生四烯酸,IC50为2µM[1]。

(S)-Bromoenol lactone名称

• 英文名: (S)-Bromoenol lactone

(S)-Bromoenol lactone生物活性

• 描述: (S) -溴代醇内酯((S)-BEL)是一种不可逆的、手性的、基于机制的钙非依赖性磷脂酶A2β(iPLA2β)抑制剂,可抑制血管加压素诱导的大鼠主动脉平滑肌(A10)细胞释放花生四烯酸,IC50为2µM[1]。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> 磷脂
  研究领域 >> 炎症/免疫
• 靶点实验:

  PLA2

• 参考文献:

  [1]. Jenkins CM, et al. Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPLA2s. J Biol Chem. 2002 Sep 6;277(36):32807-14.

(S)-Bromoenol lactone物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 467.0±45.0 °C at 760 mmHg
• 分子式: C₁₆H₁₃BrO₂
• 分子量: 317.177
• 闪点: 236.2±28.7 °C
• 精确质量: 316.009888
• PSA: 26.30000
• LogP: 4.36
• InChIKey: BYUCSFWXCMTYOI-PABFRNLHSA-N
• SMILES: O=C1OC(=CBr)CCC1c1cccc2ccccc12
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.716

(S)-Bromoenol lactone靶点实验

查看更多实验

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(S)-Bromoenol lactone英文别名

• (3S,6E)-6-(Bromomethylene)-3-(1-naphthyl)tetrahydro-2H-pyran-2-one