Ononetin

• 常用名: Ononetin
• 英文名: Ononetin
• CAS号: 487-49-0
• 分子量: 258.26900
• 密度: 1.275g/cm3
• 沸点: 464.7ºC at 760mmHg
• 分子式: C₁₅H₁₄O₄
• 熔点: 158.0-162.0°C
• 闪点: 176.9ºC

Ononetin用途

Ononetin是一种天然脱氧苯偶姻,是一种有效的选择性TRPM3通道阻滞剂,IC50为0.3μM[1]。

Ononetin名称

• 中文名: 2',4'-二羟基-2-(4-甲氧基苯基)乙酰苯
• 英文名: 1-(2,4-dihydroxyphenyl)-2-(4-methoxyphenyl)ethanone

Ononetin生物活性

• 描述: Ononetin是一种天然脱氧苯偶姻,是一种有效的选择性TRPM3通道阻滞剂,IC50为0.3μM[1]。
• 相关类别:
  信号通路 >> 跨膜转运 >> TRP频道
  研究领域 >> 神经疾病
• 靶点实验:

  TRPM3:0.3 μM (IC50)

• 体外研究: Ononetin(1-10μM)通过重组表达的TRPM3α2完全可逆地消除Ca2+进入和离子电流,并在小鼠或大鼠背根神经节(DRG)神经元的原代培养中阻断孕烯醇酮硫酸盐诱导的Ca2+进入,表明对内源性表达的TRPM3具有生物活性[1]。Ononetin的氧化中间体可能参与激活TRPA1,但不参与Ononetin阻断TRPM3[1]。
• 体内研究: Ononetin(10 mg/kg,i.p.)治疗完全逆转已建立的弗氏完全佐剂(FCA)诱导的热超敏反应,表明Trpm3-/-小鼠的超敏反应丧失不太可能是由发育或代偿机制引起的,并表明Trpm3可能是炎性疼痛的易处理靶点[2]。
• 参考文献:

  [1]. I Straub, et al. Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br J Pharmacol. 2013 Apr;168(8):1835-50.

  [2]. Omar Alkhatib, et al. Promiscuous G-Protein-Coupled Receptor Inhibition of Transient Receptor Potential Melastatin 3 Ion Channels by Gβγ Subunits. J Neurosci. 2019 Oct 2;39(40):7840-7852.

Ononetin物理化学性质

• 密度: 1.275g/cm3
• 沸点: 464.7ºC at 760mmHg
• 熔点: 158.0-162.0°C
• 分子式: C₁₅H₁₄O₄
• 分子量: 258.26900
• 闪点: 176.9ºC
• 精确质量: 258.08900
• PSA: 66.76000
• LogP: 2.53180
• InChIKey: XHBZOAYMBBUURD-UHFFFAOYSA-N
• SMILES: COc1ccc(CC(=O)c2ccc(O)cc2O)cc1
• 蒸汽压: 2.95E-09mmHg at 25°C
• 折射率: 1.62
• 储存条件: 室温

Ononetin安全信息

• 海关编码: 2914509090

Ononetin海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Ononetin靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：ERK5 transcriptional activity HTS 来源：24565 靶标：N/A External Id：ERK5 transcriptional activity-HTS

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfect... 来源：Broad Institute 靶标：N/A External Id：Bursicon-induced LGR2 mediated cAMP production in LGR-2/CRE6x-Luciferase co-transfected HEK293 cells Inhibition - 7011-01_Antagonist_SinglePoint_HTS_Activity

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Ononetin英文别名

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