6β-Naltrexol

更新时间：2025-08-25 17:22:44

6β-Naltrexol结构式	常用名	6β-Naltrexol	英文名	6β-Naltrexol
	CAS号	49625-89-0	分子量	343.42
	密度	1.48g/cm3	沸点	557.5ºC at 760mmHg
	分子式	C₂₀H₂₅NO₄	熔点	90-96ºC
	MSDS	N/A	闪点	291ºC
	符号	GHS02, GHS06, GHS08	信号词	Danger

6β-Naltrexol用途

6β-Naltrexol (6β-Hydroxynaltrexone) 是 Naltrexone 的主要代谢物,是一种外周选择性 opioid 拮抗剂。6β-Naltrexol 选择性抑制胃肠道阿片作用,抑制 Morphine 诱导的胃肠道转运减慢。

英文名	6β-Naltrexol
英文别名	更多

描述	6β-Naltrexol (6β-Hydroxynaltrexone) 是 Naltrexone 的主要代谢物,是一种外周选择性 opioid 拮抗剂。6β-Naltrexol 选择性抑制胃肠道阿片作用,抑制 Morphine 诱导的胃肠道转运减慢。
相关类别	信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体信号通路 >> 神经信号通路 >> 阿片受体研究领域 >> 神经疾病
参考文献	[1]. Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64(4):618-21. [2]. Yancey-Wrona J, et al. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011 Dec;12(12):1727-37.

描述

相关类别

信号通路 >> G 蛋白偶联受体/G 蛋白 >> 阿片受体

信号通路 >> 神经信号通路 >> 阿片受体

研究领域 >> 神经疾病

参考文献

[1]. Cone EJ, et al. Biosynthesis, isolation, and identification of 6-beta-hydroxynaltrexone, a major human metabolite of naltrexone. J Pharm Sci. 1975 Apr;64(4):618-21.

[2]. Yancey-Wrona J, et al. 6β-naltrexol, a peripherally selective opioid antagonist that inhibits morphine-induced slowing of gastrointestinal transit: an exploratory study. Pain Med. 2011 Dec;12(12):1727-37.

密度	1.48g/cm3
沸点	557.5ºC at 760mmHg
熔点	90-96ºC
分子式	C₂₀H₂₅NO₄
分子量	343.42
闪点	291ºC
精确质量	343.17800
PSA	73.16000
LogP	1.25510
InChIKey	JLVNEHKORQFVQJ-PYIJOLGTSA-N
SMILES	Oc1ccc2c3c1OC1C(O)CCC4(O)C(C2)N(CC2CC2)CCC314
折射率	1.719

符号	GHS02, GHS06, GHS08
信号词	Danger
危害声明	H225-H301 + H311 + H331-H370
警示性声明	P210-P260-P280-P301 + P310-P311
危险品运输编码	UN1230 - class 3 - PG 2 - Methanol, solution

Conformational analysis of 6α- and 6β-naltrexol and derivatives and relationship to opioid receptor affinity.

J. Chem. Inf. Model. 52(2) , 391-5, (2012)

Naltrexol and its C₆ α and β desoxy, iodo, mesyl, tosyl, trifyl, dimethylcarbamyl, and diphenylcarbamyl derivatives were studied in their energy-minimized C ring chair-like and boat-like conformations...

In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.

Eur. J. Pharm. Sci. 33(4-5) , 371-9, (2008)

6-Beta-naltrexol is the major active metabolite of naltrexone, NTX, a potent mu-opioid receptor antagonist used in the treatment of alcohol dependence and opioid abuse. Compared to naloxone, NTX has a...

Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.

Psychopharmacology 195(4) , 479-86, (2008)

Some opioid receptor ligands that appear to be neutral antagonists can have inverse agonist activity under conditions of increased constitutive activity (e.g., agonist treatment).This study compared t...

实验名称：inhibition of 1.0 nM [3H]- DAGO binding to guinea pig brain membrane opioid receptor ...
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL755007

实验名称：Inhibition of opioid receptor mu by displacing 1 nM [3H]DAGO in guinea pig brain memb...
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL755008

实验名称：Ratio of Ki for human delta opioid receptor to Ki for human kappa opioid receptor exp...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1019880

实验名称：Displacement of [3H]U69593 form human kappa opioid receptor expressed in CHO cells
来源：ChEMBL
靶标：Kappa-type opioid receptor
External Id：CHEMBL1019878

实验名称：Ratio of Ki for human mu opioid receptor to Ki for human kappa opioid receptor expres...
来源：ChEMBL
靶标：N/A
External Id：CHEMBL1019879

实验名称：Inverse agonist activity at human recombinant mu opioid receptor expressed in CHO cel...
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL2161465

实验名称：qHTS for Inhibitors of Polymerase Kappa
来源：NCGC
靶标：DNA polymerase kappa [Homo sapiens]
External Id：PolK100

实验名称：Tested for the binding affinity against the opioid receptor in guinea pig brain using...
来源：ChEMBL
靶标：Delta-type opioid receptor
External Id：CHEMBL755788

实验名称：Tested for the binding affinity against the Mu opioid receptor in guinea pig brain us...
来源：ChEMBL
靶标：Mu-type opioid receptor
External Id：CHEMBL747749

实验名称：Inhibition of 0.5 nM [3H]bremazocine binding to guinea pig brain membrane opioid rece...
来源：ChEMBL
靶标：Delta-type opioid receptor
External Id：CHEMBL754075

共21条，当前第1页，共3页

(4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol