6β-Naltrexol
6β-Naltrexol结构式
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常用名 | 6β-Naltrexol | 英文名 | 6β-Naltrexol |
|---|---|---|---|---|
| CAS号 | 49625-89-0 | 分子量 | 343.42 | |
| 密度 | 1.48g/cm3 | 沸点 | 557.5ºC at 760mmHg | |
| 分子式 | C20H25NO4 | 熔点 | 90-96ºC | |
| MSDS | N/A | 闪点 | 291ºC | |
| 符号 |
GHS02, GHS06, GHS08 |
信号词 | Danger |
6β-Naltrexol用途6β-Naltrexol (6β-Hydroxynaltrexone) 是 Naltrexone 的主要代谢物,是一种外周选择性 opioid 拮抗剂。6β-Naltrexol 选择性抑制胃肠道阿片作用,抑制 Morphine 诱导的胃肠道转运减慢。 |
| 英文名 | 6β-Naltrexol |
|---|---|
| 英文别名 | 更多 |
| 描述 | 6β-Naltrexol (6β-Hydroxynaltrexone) 是 Naltrexone 的主要代谢物,是一种外周选择性 opioid 拮抗剂。6β-Naltrexol 选择性抑制胃肠道阿片作用,抑制 Morphine 诱导的胃肠道转运减慢。 |
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| 相关类别 | |
| 参考文献 |
| 密度 | 1.48g/cm3 |
|---|---|
| 沸点 | 557.5ºC at 760mmHg |
| 熔点 | 90-96ºC |
| 分子式 | C20H25NO4 |
| 分子量 | 343.42 |
| 闪点 | 291ºC |
| 精确质量 | 343.17800 |
| PSA | 73.16000 |
| LogP | 1.25510 |
| 折射率 | 1.719 |
| 符号 |
GHS02, GHS06, GHS08 |
|---|---|
| 信号词 | Danger |
| 危害声明 | H225-H301 + H311 + H331-H370 |
| 警示性声明 | P210-P260-P280-P301 + P310-P311 |
| 危险品运输编码 | UN1230 - class 3 - PG 2 - Methanol, solution |
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Conformational analysis of 6α- and 6β-naltrexol and derivatives and relationship to opioid receptor affinity.
J. Chem. Inf. Model. 52(2) , 391-5, (2012) Naltrexol and its C₆ α and β desoxy, iodo, mesyl, tosyl, trifyl, dimethylcarbamyl, and diphenylcarbamyl derivatives were studied in their energy-minimized C ring chair-like and boat-like conformations... |
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In vivo evaluation of a transdermal codrug of 6-beta-naltrexol linked to hydroxybupropion in hairless guinea pigs.
Eur. J. Pharm. Sci. 33(4-5) , 371-9, (2008) 6-Beta-naltrexol is the major active metabolite of naltrexone, NTX, a potent mu-opioid receptor antagonist used in the treatment of alcohol dependence and opioid abuse. Compared to naloxone, NTX has a... |
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Comparison of naltrexone, 6alpha-naltrexol, and 6beta-naltrexol in morphine-dependent and in nondependent rhesus monkeys.
Psychopharmacology 195(4) , 479-86, (2008) Some opioid receptor ligands that appear to be neutral antagonists can have inverse agonist activity under conditions of increased constitutive activity (e.g., agonist treatment).This study compared t... |
| (4R,4aS,7R,7aR,12bS)-3-(cyclopropylmethyl)-1,2,4,5,6,7,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinoline-4a,7,9-triol |
- 上海化源世纪贸易有限公司
- 上海市 上海市 普陀区
- 产品名：6β-Naltrexol (1.0 mg/mL in Methanol)
- 纯度：90.0%
- 规格：
- 联系人：徐经理
- 联系电话：13311869306
- 武汉敬康恩生物医药科技有限公司
- 湖北省 武汉市 东西湖区
- 产品名：纳呋拉啡杂质30
- 纯度：95.0%
- 规格：10mg/50mg/100mg
- 联系人：周经理
- 联系电话：15871494362
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