ML-099

• 常用名: ML-099
• 英文名: ML-099
• CAS号: 496775-95-2
• 分子量: 259.323
• 密度: 1.3±0.1 g/cm3
• 沸点: 449.1±40.0 °C at 760 mmHg
• 分子式: C₁₄H₁₃NO₂S
• 熔点: N/A
• 闪点: 225.4±27.3 °C

ML-099用途

ML-099(CID-888706)是一种泛Ras相关GTPases激活剂,可激活Rac1、细胞分裂周期42、Ras、Rab7和Rab-2A[1]。

ML-099名称

• 英文名: 2-(2-phenylethylsulfanyl)pyridine-3-carboxylic acid

ML-099生物活性

• 描述: ML-099(CID-888706)是一种泛Ras相关GTPases激活剂,可激活Rac1、细胞分裂周期42、Ras、Rab7和Rab-2A[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 拉斯
• 体外研究: ML-099激活细胞分裂周期42激活突变体、细胞分裂周期42野生型、Ras蛋白野生型、GTP结合蛋白(Rab7)、Rab-2A、Rac1蛋白激活突变体、Rac1蛋白野生型和Ras蛋白激活突变体,EC50值分别为58.88 nM、100 nM、141.25 nM、181.97 nM、354.81 nM、25.42 nM、20.17 nM和95.5 nM,分别为[1]。
• 参考文献:

  [1]. Surviladze, Z., et al. UNMCMD Probe Report: Three small molecule pan activator families of Ras-related GTPases. 1-42 (2010-2009 May 18).

ML-099物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 449.1±40.0 °C at 760 mmHg
• 分子式: C₁₄H₁₃NO₂S
• 分子量: 259.323
• 闪点: 225.4±27.3 °C
• 精确质量: 259.066711
• PSA: 75.49000
• LogP: 3.43
• InChIKey: UZERZZRWECLIKE-UHFFFAOYSA-N
• SMILES: O=C(O)c1cccnc1SCCc1ccccc1
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.646

ML-099安全信息

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933399090

ML-099海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

ML-099靶点实验

查看更多实验

实验名称：Primary cell-based high-throughput screening assay for identification of compounds th... 来源：Johns Hopkins Ion Channel Center 靶标：regulator of G-protein signaling 4 isoform 2 [Homo sapiens] External Id：JHICC_RGS_Act_HTS

实验名称：Luminescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：mu-type opioid receptor isoform MOR-1 [Homo sapiens] External Id：OPRM1-OPRD1_AG_LUMI_1536_1X%ACT PRUN

实验名称：QFRET-based biochemical primary high throughput screening assay to identify exosite i... 来源：The Scripps Research Institute Molecular Screening Center 靶标：disintegrin and metalloproteinase domain-containing protein 17 preproprotein [Homo sapiens] External Id：ADAM17_INH_QFRET_1536_1X%INH PRUN

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify ago... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_AG_FLUO8_1536_1X%ACT PRUN

实验名称：Dose response of compounds that promote myeloid differentiation with HOXA9ER cells wi... 来源：NMMLSC External Id：UNMCMD_HOXA9_MYELOIDDIFFERENTIATION_HOXA9ER_SAR01

实验名称：uHTS identification of small molecule activators of the adaptive arm of the Unfolded ... 来源：Burnham Center for Chemical Genomics 靶标：N/A External Id：BCCG-A405-UPR-XBP1-PrimaryAgonist-Assay

实验名称：High throughput fluorescence intensity-based biochemical assay to screen for small mo... 来源：University of Pittsburgh Molecular Library Screening Center 靶标：furin (paired basic amino acid cleaving enzyme), isoform CRA_a [Homo sapiens] External Id：MH080376 Biochemical HTS for Inhibitors of the Proprotein Convertase Furin.

实验名称：Fluorescence polarization to screen for inhibitor that competite the binding of FadD2... 来源：Broad Institute 靶标：FATTY-ACID-CoA LIGASE FADD28 (FATTY-ACID-CoA SYNTHETASE) External Id：2147-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Primary Screen Inhibitors of CD40 Signaling in BL2 Cells Measured in Cell-Based Syste... 来源：Broad Institute 靶标：N/A External Id：7124-01_Inhibitor_SinglePoint_HTS_Activity

实验名称：Fluorescence-based cell-based primary high throughput screening assay to identify pos... 来源：The Scripps Research Institute Molecular Screening Center 靶标：muscarinic acetylcholine receptor M1 [Homo sapiens] External Id：CHRM1_PAM_FLUO8_1536_1X%ACT PRUN

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ML-099英文别名

• 2-[(2-Phenylethyl)sulfanyl]nicotinic acid