脱甲氧基脱乙酰土荆皮乙酸

• 常用名: 脱甲氧基脱乙酰土荆皮乙酸
• 英文名: Demethoxydeacetoxypseudolaric acid B analog
• CAS号: 500736-17-4
• 分子量: 376.400
• 密度: 1.4±0.1 g/cm3
• 沸点: 665.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₃₀O₈
• 熔点: N/A
• 闪点: 238.2±25.0 °C

脱甲氧基脱乙酰土荆皮乙酸用途

Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) 是从 Pseudolaric acid B 半合成而来的化合物。Demethoxydeacetoxypseudolaric acid B analog 有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞的 IC50 值范围为 0.136-1.162 μM。

脱甲氧基脱乙酰土荆皮乙酸名称

• 中文名: 脱甲氧基脱乙酰土荆皮乙酸
• 英文名: (1R,7S,8R,9R)-9-[(1E,3E)-4-Carboxy-1,3-pentadien-1-yl]-7-hydroxy-9-methyl-11-oxo-10-oxatricyclo[6.3.2.01,7]tridec-3-ene-4-carboxylic acid

脱甲氧基脱乙酰土荆皮乙酸生物活性

• 描述: Demethoxydeacetoxypseudolaric acid B analog (Compound 13b) 是从 Pseudolaric acid B 半合成而来的化合物。Demethoxydeacetoxypseudolaric acid B analog 有效抑制 HMEC-1、HL-60、A-549、MB-MDA-468、BEL-7402、HCT116、Hela 细胞的 IC50 值范围为 0.136-1.162 μM。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 其他 >> 其他
• 参考文献:

  [1]. Yang SP, et al. Structural modification of an angiogenesis inhibitor discovered from traditional Chinese medicineand a structure-activity relationship study. J Med Chem. 2008 Jan 10;51(1):77-85.

脱甲氧基脱乙酰土荆皮乙酸物理化学性质

• 密度: 1.4±0.1 g/cm3
• 沸点: 665.9±55.0 °C at 760 mmHg
• 分子式: C₂₄H₃₀O₈
• 分子量: 376.400
• 闪点: 238.2±25.0 °C
• 精确质量: 376.152191
• LogP: 1.41
• InChIKey: QPFFEVMIQIJTGZ-PSAKCFHXSA-N
• SMILES: CC(=CC=CC1(C)OC(=O)C23CC=C(C(=O)O)CCC2(O)C1CC3)C(=O)O
• 蒸汽压: 0.0±4.6 mmHg at 25°C
• 折射率: 1.613
• 储存条件: 2-8°C，干燥，密封

脱甲氧基脱乙酰土荆皮乙酸安全信息

• 危害码 (欧洲): Xi

脱甲氧基脱乙酰土荆皮乙酸靶点实验

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实验名称：Antimicrobial activity against Cryptococcus neoformans at 1 mg/mL by agar-well diffus... 来源：ChEMBL 靶标：Cryptococcus neoformans External Id：CHEMBL943208

实验名称：Antimicrobial activity against Saccharomyces cerevisiae at 1 mg/mL by agar-well diffu... 来源：ChEMBL 靶标：Saccharomyces cerevisiae External Id：CHEMBL943211

实验名称：Antimicrobial activity against Microsporum gypseum at 1 mg/mL by agar-well diffusion ... 来源：ChEMBL 靶标：Nannizzia gypsea External Id：CHEMBL943210

实验名称：Antimicrobial activity against Candida albicans at 1 mg/mL by agar-well diffusion ass... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL943205

实验名称：Antimicrobial activity against Aspergillus fumigatus at 1 mg/mL by agar-well diffusio... 来源：ChEMBL 靶标：Aspergillus fumigatus External Id：CHEMBL943207

实验名称：Antimicrobial activity against Aspergillus flavus at 1 mg/mL by agar-well diffusion a... 来源：ChEMBL 靶标：Aspergillus flavus External Id：CHEMBL943206

实验名称：Antimicrobial activity against Mycobacterium intracellular at 1 mg/mL by agar-well di... 来源：ChEMBL 靶标：Mycobacterium intracellulare External Id：CHEMBL943216

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脱甲氧基脱乙酰土荆皮乙酸英文别名

• (1R,7S,8R,9R)-9-[(1E,3E)-4-Carboxy-1,3-pentadien-1-yl]-7-hydroxy-9-methyl-11-oxo-10-oxatricyclo[6.3.2.0]tridec-3-ene-4-carboxylic acid