比哌立登

• 常用名: 比哌立登
• 英文名: biperiden
• CAS号: 514-65-8
• 分子量: 311.461
• 密度: 1.1±0.1 g/cm3
• 沸点: 462.1±40.0 °C at 760 mmHg
• 分子式: C₂₁H₂₉NO
• 熔点: 114ºC
• 闪点: 224.5±26.0 °C

比哌立登用途

Biperiden(KL 373)有抗帕金森症活性,是中枢M1胆碱受体阻断剂。

比哌立登名称

• 中文名: 比哌立登
• 英文名: biperiden
• 中文别名: 3-哌啶基-1-苯基-双环庚烯基-1-丙醇 | 碧卜利旦 | 1-(5-双环[2.2.1]庚-2-烯基)-1-苯基-3-(1-哌啶基)丙-1-醇

比哌立登生物活性

• 描述: Biperiden(KL 373)有抗帕金森症活性,是中枢M1胆碱受体阻断剂。
• 相关类别:
  信号通路 >> G 蛋白偶联受体/G 蛋白 >> 由mAChR
  信号通路 >> 神经信号通路 >> mAChR
  研究领域 >> 神经疾病
• 参考文献:

  [1]. Pehl C, et al. Effects of two anticholinergic drugs, trospium chloride and biperiden, on motility and evoked potentials of the oesophagus. Aliment Pharmacol Ther. 1998 Oct;12(10)

  [2]. Kornhuber J, et al. Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One. 2011;6(8)

  [3]. Myhrer T, et al. Antiparkinson drugs used as prophylactics for nerve agents: studies of cognitive side effects in rats. Pharmacol Biochem Behav. 2008 Jun;89(4):633-8.

比哌立登物理化学性质

• 密度: 1.1±0.1 g/cm3
• 沸点: 462.1±40.0 °C at 760 mmHg
• 熔点: 114ºC
• 分子式: C₂₁H₂₉NO
• 分子量: 311.461
• 闪点: 224.5±26.0 °C
• 精确质量: 311.224915
• PSA: 23.47000
• LogP: 4.01
• InChIKey: YSXKPIUOCJLQIE-UHFFFAOYSA-N
• SMILES: OC(CCN1CCCCC1)(c1ccccc1)C1CC2C=CC1C2
• 蒸汽压: 0.0±1.2 mmHg at 25°C
• 折射率: 1.583
• 储存条件: 通风低温干燥
• 水溶解性: 25.1 mg/L
• 计算化学:

  1.疏水参数计算参考值（XlogP）:无

  2.氢键供体数量:1

  3.氢键受体数量:2

  4.可旋转化学键数量:5

  5.互变异构体数量:无

  6.拓扑分子极性表面积:23.5

  7.重原子数量:23

  8.表面电荷:0

  9.复杂度:422

  10.同位素原子数量:0

  11.确定原子立构中心数量:0

  12.不确定原子立构中心数量:4

  13.确定化学键立构中心数量:0

  14.不确定化学键立构中心数量:0

  15.共价键单元数量:1

比哌立登毒性和生态

比哌立登安全信息

• 危险品运输编码: NONH for all modes of transport
• 海关编码: 2933399090

比哌立登海关

• 海关编码: 2933399090
• 中文概述: 2933399090. 其他结构含非稠合吡啶环的化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

比哌立登靶点实验

查看更多实验

实验名称：Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression 来源：NCGC External Id：SNCA-p-activity-luciferase

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OPM1-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-OC1MY5-m4-1

实验名称：Increase the activity of the Burkholderia fixLJ 2-component system 来源：ICCB-Longwood/NSRB Screening Facility, Harvard Medical School 靶标：Burkholderia multivorans External Id：HMS1625

实验名称：Human M5 receptor (Acetylcholine receptors (muscarinic)) 来源：IUPHAR-DB 靶标：M5 receptor (Acetylcholine receptors (muscarinic)) [Homo sapiens] External Id：17_Human

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-KMS_34-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_L363-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-keats_OCIMY7-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-MM1R-m4-1

实验名称：Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against th... 来源：NCGC 靶标：N/A External Id：s-my-mm1s-m4-1

共366条，当前第1页，共37页

1

2

3

4

5

比哌立登英文别名

• Biperidene [INN-French]
• 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol
• EINECS 208-184-6
• Biperideno
• 1-norborn-5-en-2-yl-1-phenyl-3-piperidino-propan-1-ol
• Biperidene
• Biperidine
• Beperiden
• a-5-Norbornen-2-yl-a-phenyl-1-piperidinepropanol
• biperiden
• UNII:0FRP6G56LD
• 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol
• 1-norborn-5-en-2-yl-1-phenyl-3-piperidin-1-yl-propan-1-ol
• 3-Piperidino-1-phenyl-(D5-bicyclo[2.2.1]hepten-2-yl)-1-propanol
• Akineton
• 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-piperidin-1-ylpropan-1-ol
• 1-Bicycloheptenyl-1-phenyl-3-piperidinopropanol
• Biperidenum
• a-Bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-1-piperidinepropanol
• Biperideno [INN-Spanish]
• Biperidenum [INN-Latin]
• 1-[(1R,4R)-Bicyclo[2.2.1]hept-5-en-2-yl]-1-phenyl-3-(1-piperidinyl)-1-propanol
• 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(1-piperidinyl)-1-propanol