甘草利酮

• 常用名: 甘草利酮
• 英文名: Licoricone
• CAS号: 51847-92-8
• 分子量: 382.406
• 密度: 1.3±0.1 g/cm3
• 沸点: 605.6±55.0 °C at 760 mmHg
• 分子式: C₂₂H₂₂O₆
• 熔点: 250-251℃
• 闪点: 212.9±25.0 °C

甘草利酮用途

Licoricone 甘草酮是从甘草中提取的一种黄酮类化合物,具有抗幽门螺杆菌和抗阿莫西菌的活性,对四株阿莫西菌敏感。

甘草利酮名称

• 中文名: 甘草利酮
• 英文名: licoricone

甘草利酮生物活性

• 描述: Licoricone 甘草酮是从甘草中提取的一种黄酮类化合物,具有抗幽门螺杆菌和抗阿莫西菌的活性,对四株阿莫西菌敏感。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 细菌
• 参考文献:

  [1]. Fukai T, et al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. 2002 Aug 9;71(12):1449-63.

甘草利酮物理化学性质

• 密度: 1.3±0.1 g/cm3
• 沸点: 605.6±55.0 °C at 760 mmHg
• 熔点: 250-251℃
• 分子式: C₂₂H₂₂O₆
• 分子量: 382.406
• 闪点: 212.9±25.0 °C
• 精确质量: 382.141632
• PSA: 89.13000
• LogP: 5.19
• InChIKey: GGWMNTNDTRKETA-UHFFFAOYSA-N
• SMILES: COc1cc(O)c(-c2coc3cc(O)ccc3c2=O)c(OC)c1CC=C(C)C
• 外观性状: 粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.615
• 储存条件: 2-8℃，干燥，密闭

甘草利酮安全信息

• 危害码 (欧洲): Xi

甘草利酮靶点实验

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实验名称：Inhibition of recombinant human PTP1B using p-nitrophenyl phosphate as substrate at 1... 来源：ChEMBL 靶标：Tyrosine-protein phosphatase non-receptor type 1 External Id：CHEMBL4035961

实验名称：Inhibition of LPS-induced NF-kappaB transcription (unknown origin) expressed in human... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4035959

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induc... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL4035957

实验名称：Activation of Nrf2 (unknown origin) expressed in human HepG2 cells at 10 uM incubated... 来源：ChEMBL 靶标：Nuclear factor erythroid 2-related factor 2 External Id：CHEMBL4046717

实验名称：Growth inhibition of human HepG2 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：HepG2 External Id：CHEMBL4035954

实验名称：Growth inhibition of human MCF7 cells at 10 uM after 24 hrs by MTS assay relative to ... 来源：ChEMBL 靶标：MCF7 External Id：CHEMBL4035952

实验名称：Growth inhibition of human SW480 cells at 10 uM after 24 hrs by MTS assay relative to... 来源：ChEMBL 靶标：SW480 External Id：CHEMBL4035953

实验名称：HIV Cellular Data 来源：NIAID 靶标：N/A External Id：HIV Cellular Data

实验名称：Inhibition of mushroom tyrosinase at 10 uM using L-tyrosine as substrate incubated fo... 来源：ChEMBL 靶标：Polyphenol oxidase 4 External Id：CHEMBL4035963

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甘草利酮英文别名

• 7-Hydroxy-3-[6-hydroxy-2,4-dimethoxy-3-(3-methyl-2-buten-1-yl)phenyl]-4H-chromen-4-one
• 7-Hydroxy-3-[6-hydroxy-2,4-dimethoxy-3-(3-methyl-but-2-enyl)-phenyl]-1-benzopyran-4-one
• Licoricone
• 7-hydroxy-3-[6-hydroxy-2,4-dimethoxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one