苜蓿素

• 常用名: 苜蓿素
• 英文名: Tricin
• CAS号: 520-32-1
• 分子量: 330.289
• 密度: 1.5±0.1 g/cm3
• 沸点: 598.5±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₇
• 熔点: N/A
• 闪点: 224.0±23.6 °C

苜蓿素用途

Tricin 是米糠中大量存在的一种天然类黄酮。Tricin 通过抑制 CDK9 来抑制 HCMV 的复制。Tricin 通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。

苜蓿素名称

• 中文名: 苜蓿素
• 英文名: 3',5'-di-O-methyltricetin
• 中文别名: 5,7-二羟基-2-(4-羟基-3,5-二甲氧基苯基)苯并吡喃-4-酮

苜蓿素生物活性

• 描述: Tricin 是米糠中大量存在的一种天然类黄酮。Tricin 通过抑制 CDK9 来抑制 HCMV 的复制。Tricin 通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。
• 相关类别:
  研究领域 >> 癌症
  研究领域 >> 感染
  信号通路 >> 抗感染 >> CMV
• 参考文献:

  [1]. Itoh A, et al. Tricin inhibits the CCL5 induction required for efficient growth of human cytomegalovirus. Microbiol Immunol. 2018 May;62(5):341-347.

  [2]. Sadanari H, et al. The anti-human cytomegalovirus drug tricin inhibits cyclin-dependent kinase 9. FEBS Open Bio. 2018 Feb 20;8(4):646-654.

  [3]. Chung DJ, et al. Inhibition of the Proliferation and Invasion of C6 Glioma Cells by Tricin via the Upregulation of Focal-Adhesion-Kinase-Targeting MicroRNA-7. J Agric Food Chem. 2018 Jul 5;66(26):6708-6716.

苜蓿素物理化学性质

• 密度: 1.5±0.1 g/cm3
• 沸点: 598.5±50.0 °C at 760 mmHg
• 分子式: C₁₇H₁₄O₇
• 分子量: 330.289
• 闪点: 224.0±23.6 °C
• 精确质量: 330.073944
• PSA: 109.36000
• LogP: 1.39
• InChIKey: HRGUSFBJBOKSML-UHFFFAOYSA-N
• SMILES: COc1cc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc(OC)c1O
• 外观性状: 黄色粉末
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.671
• 储存条件: 2-8℃，干燥，密闭

苜蓿素安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2914509090

苜蓿素海关

• 海关编码: 2914509090
• 中文概述: 2914509090 含其他含氧基的酮. 增值税率:17.0% 退税率:9.0% 监管条件:无 最惠国关税:5.5% 普通关税:30.0%
• 申报要素: 品名, 成分含量, 用途, 丙酮报明包装
• Summary: HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

苜蓿素靶点实验

查看更多实验

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimu... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3379704

实验名称：Inhibition of LPS/INF-gamma-stimulated nitric oxide production in mouse RAW264.7 cell... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3874800

实验名称：Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-stimu... 来源：ChEMBL 靶标：RAW264.7 External Id：CHEMBL3379703

实验名称：Inhibition of recombinant human MAO-A using kynuramine as substrate incubated for 10 ... 来源：ChEMBL 靶标：Amine oxidase [flavin-containing] A External Id：CHEMBL5231663

实验名称：Cytotoxicity against rat RBL2H3 cells at 500 uM by optical microscope 来源：ChEMBL 靶标：N/A External Id：CHEMBL983170

实验名称：Antihistaminic activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced... 来源：ChEMBL 靶标：RBL-2H3 External Id：CHEMBL983169

实验名称：Inhibition of Saccharomyces cerevisiae alpha-glucosidase using p-nitro-phenyl-alpha-D... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4184663

实验名称：Cytotoxicity against mouse P388 cells xenografted in BDF1 mouse at 12.5 mg/kg relativ... 来源：ChEMBL 靶标：P388 External Id：CHEMBL1029286

实验名称：Cytotoxicity against mouse P388 cells xenografted in BDF1 mouse at 6 mg/kg relative t... 来源：ChEMBL 靶标：P388 External Id：CHEMBL1029285

实验名称：Antifungal activity against Candida albicans at 5 ug after 3 days by MTT assay 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL1006061

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苜蓿素英文别名

• Tricetin 3',5'-di-methyl ether
• 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one
• 3',5'-DIMETHOXY-4',5,7-TRIHYDROXYFLAVONE
• 5,7,4'-trihydroxy-3',5'-dimethoxyflavone
• Tricin
• 4',5,7-trihydroxy-3',5'-dimethoxyflavone
• 3',5'-O-dimethyltricetin
• 5,7-dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromen-4-one
• 3',5'-di-O-methyltricetin
• 5,7-Dihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-chromen-4-one
• tricetine-3',5'-dimethyl ether