β-Nor-lapachone

• 常用名: β-Nor-lapachone
• 英文名: β-Nor-lapachone
• CAS号: 52436-88-1
• 分子量: 228.24
• 密度: N/A
• 沸点: N/A
• 分子式: C₁₄H₁₂O₃
• 熔点: N/A
• 闪点: N/A

β-Nor-lapachone用途

β-Nor-lapachone是一种光滑念珠菌抗生物膜剂。β-Nor-lapachone可刺激活性氧的产生,抑制光滑念珠菌的外排活性、粘附、生物膜的形成和成熟生物膜的代谢。β-去甲拉帕酮具有抗真菌活性[1]。

β-Nor-lapachone名称

• 英文名: 2,2-dimethyl-3H-benzo[g][1]benzofuran-4,5-dione

β-Nor-lapachone生物活性

• 描述: β-Nor-lapachone是一种光滑念珠菌抗生物膜剂。β-Nor-lapachone可刺激活性氧的产生,抑制光滑念珠菌的外排活性、粘附、生物膜的形成和成熟生物膜的代谢。β-去甲拉帕酮具有抗真菌活性[1]。
• 相关类别:
  研究领域 >> 感染
  信号通路 >> 抗感染 >> 真菌
  信号通路 >> 蛋白酪氨酸激酶 >> ROS
• 靶点实验:

  Candida glabrata, ROS[1]

• 参考文献:

  [1]. Clemente de Moraes D, et al. Effects of β-lapachone and β-nor-lapachone on multidrug efflux transporters and biofilms of Candida glabrata. Bioorg Med Chem. 2022;63:116749.

β-Nor-lapachone物理化学性质

• 分子式: C₁₄H₁₂O₃
• 分子量: 228.24
• 精确质量: 228.07900
• PSA: 43.37000
• LogP: 2.36200
• InChIKey: DMSVAEFGRLMACV-UHFFFAOYSA-N
• SMILES: CC1(C)CC2=C(O1)c1ccccc1C(=O)C2=O

β-Nor-lapachone靶点实验

查看更多实验

实验名称：Cytotoxicity against human PBMC after 72 hrs by alamar blue assay 来源：ChEMBL 靶标：PBMC External Id：CHEMBL1112800

实验名称：Antitrypanosomal activity against Trypanosoma cruzi Y blood stream trypomastigotes af... 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL1112799

实验名称：Antifungal activity against Candida albicans assessed as growth inhibition at 250 ug/... 来源：ChEMBL 靶标：Candida albicans External Id：CHEMBL3225929

实验名称：Antifungal activity against Candida kefyr assessed as growth inhibition at 250 ug/mL ... 来源：ChEMBL 靶标：Kluyveromyces marxianus External Id：CHEMBL3225931

实验名称：Antifungal activity against Candida tropicalis assessed as growth inhibition at 250 u... 来源：ChEMBL 靶标：Candida tropicalis External Id：CHEMBL3225930

实验名称：Selectivity ratio of compound reduction rate catalyzed by recombinant human NQO1 expr... 来源：ChEMBL 靶标：N/A External Id：CHEMBL4009137

实验名称：Substrate activity at recombinant human CPR expressed in baculovirus infected insect ... 来源：ChEMBL 靶标：NADPH--cytochrome P450 reductase External Id：CHEMBL4009136

实验名称：Selectivity ratio of IC50 for human A549 cells in presence of NQO1 inhibitor dicoumar... 来源：ChEMBL 靶标：A549 External Id：CHEMBL3399095

实验名称：Substrate activity at recombinant human NQO1 expressed in Escherichia coli assessed a... 来源：ChEMBL 靶标：NAD(P)H dehydrogenase [quinone] 1 External Id：CHEMBL4009135

实验名称：Trypanocidal activity against bloodstream form of Trypanosoma cruzi Y isolated from a... 来源：ChEMBL 靶标：Trypanosoma cruzi External Id：CHEMBL2026306

共163条，当前第1页，共17页

1

2

3

4

5

β-Nor-lapachone英文别名

• Naphtho[1,2-b]furan-4,5-dione,2,3-dihydro-2,2-dimethyl