Chenodeoxycholic acid-d5

更新时间：2024-01-04 11:50:04

Chenodeoxycholic acid-d5结构式	常用名	Chenodeoxycholic acid-d5	英文名	Chenodeoxycholic acid-d5
	CAS号	52840-12-7	分子量	397.60300
	密度	N/A	沸点	N/A
	分子式	C₂₄H₃₅D₅O₄	熔点	N/A
	MSDS	N/A	闪点	N/A

Chenodeoxycholic acid-d5用途

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鹅去氧胆酸-d5(CDCA-d5)是氘标记的鹅去氧胆酸。鹅去氧胆酸是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。

英文名	(4R)-4-[(3R,5R,7R,8R,9S,10S,13R,14S,17R)-2,2,3,4,4-pentadeuterio-3,7-dihydroxy-10,13-dimethyl-1,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]pentanoic acid
英文别名	更多

描述	鹅去氧胆酸-d5(CDCA-d5)是氘标记的鹅去氧胆酸。鹅去氧胆酸是一种疏水性初级胆汁酸,可激活参与胆固醇代谢的核受体(FXR)。
相关类别	研究领域 >> 癌症信号通路 >> 代谢酶/蛋白酶 >> FXR 信号通路 >> 自噬 >> 自噬研究领域 >> 代谢疾病
体外研究	氢、碳和其他元素的稳定重同位素已被纳入药物分子中,主要作为药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注[1]。
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Stauffer AT, et al. Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor. J Biol Chem. 2002 Jul 19;277(29):26286-92 [3]. Casaburi I, et al. Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances cyclin D1 expression and promotes human endometrial cancer cell proliferation. Cell Cycle. 2012 Jul 15;11(14):2699-710 [4]. Kawabe Y, et al. The molecular mechanism of the induction of the low density lipoprotein receptor by chenodeoxycholic acid in cultured human cells. Biochem Biophys Res Commun. 1995 Mar 8;208(1):405-11. [5]. Ao M, et al. Chenodeoxycholic acid stimulates Cl(-) secretion via cAMP signaling and increases cystic fibrosis transmembrane conductance regulator phosphorylation in T84 cells. Am J Physiol Cell Physiol. 2013 Aug 15;305(4):C447-56 [6]. Noh K, et al. Farnesoid X receptor activation by chenodeoxycholic acid induces detoxifying enzymes through AMP-activated protein kinase and extracellular signal-regulated kinase 1/2-mediated phosphorylation of CCAAT/enhancer binding protein β. Drug Metab

分子式	C₂₄H₃₅D₅O₄
分子量	397.60300
精确质量	397.32400
PSA	77.76000
LogP	4.47790

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