RORγ inverse agonist 1

• 常用名: RORγ inverse agonist 1
• 英文名: RORγ inverse agonist 1
• CAS号: 529500-72-9
• 分子量: 463.47
• 密度: 1.4±0.1 g/cm3
• 沸点: N/A
• 分子式: C₂₂H₂₀F₃N₃O₃S
• 熔点: N/A
• 闪点: N/A

RORγ inverse agonist 1用途

RORγ inverse agonist 1 是 RORγ 的反向激动剂。

RORγ inverse agonist 1名称

• 英文名: WAY-311015

RORγ inverse agonist 1生物活性

• 描述: RORγ inverse agonist 1 是 RORγ 的反向激动剂。
• 相关类别:
  信号通路 >> 代谢酶/蛋白酶 >> ROR
  研究领域 >> 癌症
• 靶点实验:

  RORγ[1]

• 参考文献:

  [1]. Song Y, et al. Identification of N-phenyl-2-(N-phenylphenylsulfonamido)acetamides as new RORγ inverse agonists: Virtual screening, structure-based optimization, and biological evaluation. Eur J Med Chem. 2016 Jun 30;116:13-26.

RORγ inverse agonist 1物理化学性质

• 密度: 1.4±0.1 g/cm3
• 分子式: C₂₂H₂₀F₃N₃O₃S
• 分子量: 463.47
• 精确质量: 463.117737
• LogP: 2.82
• InChIKey: BELQBTOQMMQYFF-UHFFFAOYSA-N
• SMILES: Cc1ccc(S(=O)(=O)N(CC(=O)NCc2ccncc2)c2cccc(C(F)(F)F)c2)cc1
• 折射率: 1.586
• 储存条件: -80℃储存

RORγ inverse agonist 1靶点实验

查看更多实验

实验名称：Displacement of N-terminal biotinylated SRC1-4 coactivator peptide from N-terminal Hi... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL3803971

实验名称：Inhibition of Gal4-RORgamma-LBD (180 to 507 residues) (unknown origin) expressed in H... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL3803970

实验名称：Displacement of N-terminal biotinylated SRC1-4 coactivator peptide from N-terminal Hi... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL3803974

实验名称：Inhibition of Gal4-RORgamma-LBD (180 to 507 residues) (unknown origin) expressed in H... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL3803973

实验名称：Binding affinity to N-terminal His6-fused human RORgamma-LBD (262 to 507 residues) ex... 来源：ChEMBL 靶标：Nuclear receptor ROR-gamma External Id：CHEMBL3803972

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RORγ inverse agonist 1英文别名

• N2-[(4-methylphenyl)sulfonyl]-N-(pyridin-4-ylmethyl)-N2-[3-(trifluoromethyl)phenyl]glycinamide
• N2-[(4-Methylphenyl)sulfonyl]-N-(4-pyridinylmethyl)-N2-[3-(trifluoromethyl)phenyl]glycinamide